{"id":"W2138021651","doi":"10.1242/jcs.061143","title":"Activity of protein kinase CK2 uncouples Bid cleavage from caspase-8 activation","year":2010,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Cleavage (geology); Biology; Caspase 3; Caspase 8; Cleavage stimulation factor; Cell biology; NLRP1; Caspase; Protein subunit; Apoptosis; Molecular biology; Biochemistry; Cleavage factor; Programmed cell death; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001360683,0.000354423,0.0002742504,0.000149741,0.0001412545,0.000333011,0.0001381604,0.0001570337,0.000950773],"category_scores_gemma":[0.0001752792,0.0001153706,0.0001398827,0.0001270848,0.0002057514,0.0002812551,0.0001679387,0.0004212383,0.0002464475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004575516,"about_ca_system_score_gemma":0.0002628075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006668975,"about_ca_topic_score_gemma":0.001232876,"domain_scores_codex":[0.999868,0.00002123415,0.0000108254,0.00003098516,0.00003838948,0.00003045838],"domain_scores_gemma":[0.9999119,0.00002206352,0.0000165153,0.00001785447,0.0000152931,0.00001637431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001072595,0.000007694181,0.00009410657,0.00002188837,0.000002565183,0.00002059482,0.000008688519,0.00003495328,0.9992176,0.00003900086,0.000009336225,0.0004363268],"study_design_scores_gemma":[0.0000095698,0.00009622655,0.001867782,0.000001446503,0.000005192858,0.00008023316,0.00001019993,0.0004598529,0.996795,0.00001842496,0.0006541989,0.000001785605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926922,0.001860175,0.004233264,0.00005586257,0.00002723924,0.00002158036,0.0002087511,0.00005743239,0.0008435624],"genre_scores_gemma":[0.9951019,0.0006707364,0.002672834,0.00002044945,0.000008703523,0.0000369214,0.000340334,0.00001464227,0.001133477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000950773,"threshold_uncertainty_score":0.0033198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00629029082968915,"score_gpt":0.2292608030556339,"score_spread":0.2229705122259447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}