{"id":"W2138021651","doi":"10.1242/jcs.061143","title":"Activity of protein kinase CK2 uncouples Bid cleavage from caspase-8 activation","year":2010,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Cleavage (geology); Biology; Caspase 3; Caspase 8; Cleavage stimulation factor; Cell biology; NLRP1; Caspase; Protein subunit; Apoptosis; Molecular biology; Biochemistry; Cleavage factor; Programmed cell death; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004315941,0.0000653539,0.0000920623,0.00006550208,0.00006919938,0.00002150136,0.0002022389,0.00007441393,0.00002130135],"category_scores_gemma":[0.00007704397,0.00005027697,0.00005692084,0.0001368597,0.0001420744,0.00002384371,0.00004693893,0.0001180384,8.623223e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001063044,"about_ca_system_score_gemma":0.000192948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000374422,"about_ca_topic_score_gemma":0.0000275685,"domain_scores_codex":[0.999301,0.00001423322,0.0001664106,0.00013154,0.0002795327,0.0001072479],"domain_scores_gemma":[0.9992109,0.00000896696,0.0003557503,0.0001661961,0.0001830775,0.00007508919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006714167,0.0000659916,0.00007393969,0.000005274281,0.000002765519,0.000001571153,0.00002933425,0.00005334108,0.9945205,0.00003625154,0.0000372409,0.005106668],"study_design_scores_gemma":[0.0002257265,0.0002084134,0.00436826,0.00001339529,0.000006093136,0.000003959722,0.00002578103,0.0002933731,0.9932979,0.0002561307,0.001240721,0.00006022046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962552,0.00002858378,0.002890626,0.00005891261,0.0002242105,0.00007458372,0.000003043276,0.000001358025,0.0004634923],"genre_scores_gemma":[0.9966023,0.00002155095,0.003047408,0.00001290825,0.0001862824,6.748753e-7,0.000001770614,0.000004727171,0.0001223647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005046448,"threshold_uncertainty_score":0.2050235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00629029082968915,"score_gpt":0.2292608030556339,"score_spread":0.2229705122259447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}