{"id":"W2138028847","doi":"10.1128/jvi.01528-08","title":"Mechanism of Antiviral Drug Resistance of Vaccinia Virus: Identification of Residues in the Viral DNA Polymerase Conferring Differential Resistance to Antipoxvirus Drugs","year":2008,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Poxvirus research and outbreaks","field":"Immunology and Microbiology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Vlaamse regering; Akademie Věd České Republiky; Fonds Wetenschappelijk Onderzoek; Gilead Sciences","keywords":"Biology; Vaccinia; Virology; Virus; Polymerase; Drug resistance; Poxviridae; Antiviral drug; Mechanism (biology); DNA polymerase; Polymerase chain reaction; Viral replication; DNA; Microbiology; Genetics; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001254689,0.0001927947,0.0007902788,0.0005531237,0.0001088014,0.000006029303,0.0008009627,0.0002061005,0.00006905124],"category_scores_gemma":[0.0003226453,0.0001470154,0.0002120289,0.0002944678,0.0004488814,0.0001725713,0.0001081894,0.0005243983,0.00001125075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003356708,"about_ca_system_score_gemma":0.0001818865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001822097,"about_ca_topic_score_gemma":0.0005921508,"domain_scores_codex":[0.9967135,0.0009259155,0.001506125,0.0002274756,0.000218133,0.0004088932],"domain_scores_gemma":[0.9976334,0.000421295,0.001242149,0.0004156279,0.0002501098,0.00003740817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005811997,0.0003242293,0.001581571,0.00005597586,0.0001398195,0.00004542543,0.003247387,0.000001758821,0.9849135,0.002624739,0.001073059,0.0001805643],"study_design_scores_gemma":[0.001890514,0.0003447258,0.05776218,0.00009814122,0.00004441462,0.00004701431,0.0003152243,0.000001235956,0.9378284,0.001064237,0.0004940845,0.0001098186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957346,0.00243529,0.0003338678,0.0006614399,0.0002912788,0.0002107986,0.00009015783,0.000005072033,0.0002375208],"genre_scores_gemma":[0.9985368,0.0007129784,0.00006191809,0.0000933363,0.00004753443,0.000004839399,0.000007131966,0.00001484005,0.0005206465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05618061,"threshold_uncertainty_score":0.5995116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01256428260646324,"score_gpt":0.2628863471608701,"score_spread":0.2503220645544069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}