{"id":"W2138028847","doi":"10.1128/jvi.01528-08","title":"Mechanism of Antiviral Drug Resistance of Vaccinia Virus: Identification of Residues in the Viral DNA Polymerase Conferring Differential Resistance to Antipoxvirus Drugs","year":2008,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Poxvirus research and outbreaks","field":"Immunology and Microbiology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Vlaamse regering; Akademie Věd České Republiky; Fonds Wetenschappelijk Onderzoek; Gilead Sciences","keywords":"Biology; Vaccinia; Virology; Virus; Polymerase; Drug resistance; Poxviridae; Antiviral drug; Mechanism (biology); DNA polymerase; Polymerase chain reaction; Viral replication; DNA; Microbiology; Genetics; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003167889,0.0003894496,0.0004402595,0.0003350776,0.0001564695,0.0003491564,0.0004713415,0.0005588857,0.0006583833],"category_scores_gemma":[0.0002432298,0.0002111221,0.0003536771,0.0001624453,0.0003369835,0.0003163865,0.0001955158,0.0004387621,0.0003168683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003271636,"about_ca_system_score_gemma":0.0001196109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002612755,"about_ca_topic_score_gemma":0.0001620288,"domain_scores_codex":[0.9997624,0.00005358026,0.0000277472,0.00005569909,0.00005951077,0.00004107017],"domain_scores_gemma":[0.9998648,0.00003702567,0.00003747773,0.00002218812,0.00001716263,0.00002139304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005475465,0.00002348585,0.0003186006,0.00001671927,0.000005053544,0.00005062953,0.000009021452,0.00008969058,0.9985101,0.00007900724,0.00001093779,0.0008321126],"study_design_scores_gemma":[0.00002424879,0.0003880216,0.003714365,0.000004845274,0.00001640258,0.0007119196,0.00001298167,0.002157095,0.9920498,0.0000624114,0.0008518852,0.000006119191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951521,0.0008787794,0.002979537,0.00006308401,0.00001214171,0.00004951927,0.0001644452,0.00005607021,0.000644386],"genre_scores_gemma":[0.9969324,0.0003686367,0.002017049,0.00003219799,0.000005286148,0.00002799,0.0001612399,0.00001185343,0.0004434494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006583833,"threshold_uncertainty_score":0.002373815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01256428260646324,"score_gpt":0.2628863471608701,"score_spread":0.2503220645544069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}