{"id":"W2138029385","doi":"10.1093/hmg/ddn165","title":"Regulation of DNA methylation activity through Dnmt3L promoter methylation by Dnmt3 enzymes in embryonic development","year":2008,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"Chinese Academy of Sciences","keywords":"DNMT3B; DNA methylation; Methylation; Biology; Methyltransferase; DNA methyltransferase; Epigenetics; Genetics; Molecular biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003589591,0.0002803248,0.000279477,0.0001271276,0.0001420388,0.00001673119,0.0001894283,0.0003170712,0.00002254442],"category_scores_gemma":[0.00005402925,0.0003166044,0.0001085824,0.0002407719,0.0001142835,0.00001526548,0.0001056734,0.0001305715,0.000004766264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006224278,"about_ca_system_score_gemma":0.0001356681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002507437,"about_ca_topic_score_gemma":0.00006660917,"domain_scores_codex":[0.9979788,0.0002507994,0.0005284962,0.0005357838,0.0003962855,0.0003098028],"domain_scores_gemma":[0.9989109,0.00001614606,0.0003270923,0.0004967689,0.0001828464,0.00006623452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003746459,0.0001487849,0.00251848,0.00002957577,0.00004379448,0.000002059075,0.0003597049,0.001400921,0.9919198,0.0001543225,0.00006152227,0.003323606],"study_design_scores_gemma":[0.0006332121,0.000239149,0.09658574,0.00001693476,0.0000196577,0.000002122983,0.00001210173,0.0002346135,0.8976709,0.0007285148,0.00355578,0.0003012289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9466063,0.004817553,0.04742461,0.00004032261,0.0000667912,0.0004542138,0.000008008757,0.00001474499,0.0005673949],"genre_scores_gemma":[0.9922929,0.0003588423,0.006484326,0.00003116559,0.00005402106,0.00003679449,0.0004126224,0.00005212521,0.0002771594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09424882,"threshold_uncertainty_score":0.9999286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02455949694654242,"score_gpt":0.2792650501811011,"score_spread":0.2547055532345587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}