{"id":"W2138029385","doi":"10.1093/hmg/ddn165","title":"Regulation of DNA methylation activity through Dnmt3L promoter methylation by Dnmt3 enzymes in embryonic development","year":2008,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"Chinese Academy of Sciences","keywords":"DNMT3B; DNA methylation; Methylation; Biology; Methyltransferase; DNA methyltransferase; Epigenetics; Genetics; Molecular biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002552944,0.0003023654,0.0003101066,0.000325483,0.0002281784,0.0004322582,0.0002899316,0.0004093169,0.0008738597],"category_scores_gemma":[0.0002033393,0.0002973872,0.0003286686,0.0002344948,0.0003471144,0.0003723816,0.0005321824,0.000593896,0.0004813117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006874658,"about_ca_system_score_gemma":0.0004251026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001443424,"about_ca_topic_score_gemma":0.002009179,"domain_scores_codex":[0.9998047,0.00003014362,0.00001642217,0.00006404683,0.0000514301,0.00003322547],"domain_scores_gemma":[0.9998761,0.00001625216,0.00004359528,0.00001810965,0.00001991921,0.00002590558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006710319,0.000006216695,0.001403023,0.00009737958,0.00001173269,0.00006765858,0.00004222176,0.000141778,0.9924315,0.0006187712,0.00005766111,0.005055004],"study_design_scores_gemma":[0.0000194461,0.00008347625,0.01683212,0.0000250211,0.00004570188,0.000376209,0.00002841626,0.001640644,0.9720148,0.0004495918,0.008467203,0.00001735256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8856566,0.03956982,0.06230108,0.0005310144,0.0001141158,0.0001102276,0.001642104,0.001191522,0.008883477],"genre_scores_gemma":[0.9801934,0.005140454,0.01010712,0.0001180495,0.00002144952,0.00005348086,0.0005615072,0.00006689624,0.003737638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001443424,"threshold_uncertainty_score":0.004987955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02455949694654242,"score_gpt":0.2792650501811011,"score_spread":0.2547055532345587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}