{"id":"W2138051343","doi":"10.1002/stem.2115","title":"In Vitro T-Cell Generation From Adult, Embryonic, and Induced Pluripotent Stem Cells: Many Roads to One Destination","year":2015,"lang":"en","type":"review","venue":"Stem Cells","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Biology; Induced pluripotent stem cell; Embryonic stem cell; Cell biology; Stem cell; Progenitor cell; Haematopoiesis; Cellular differentiation; In vitro; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009558498,0.0006761483,0.002193376,0.0006583481,0.00006450488,0.0001284017,0.0003119604,0.0006753611,0.0002365823],"category_scores_gemma":[0.00001186927,0.0006204509,0.0002648327,0.0006488429,0.00004031521,0.0001303698,0.0002213415,0.0009205466,0.0005656347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001305512,"about_ca_system_score_gemma":0.0007543782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004407357,"about_ca_topic_score_gemma":0.00007856578,"domain_scores_codex":[0.995443,0.0006332485,0.001046066,0.00113554,0.001103907,0.0006381947],"domain_scores_gemma":[0.9975127,0.0001883179,0.0003825061,0.0009143636,0.0004141751,0.0005879555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001419063,0.0002216861,0.000001352833,0.003750864,0.00009782059,0.00009261798,0.0002840863,0.000003614061,0.3045596,0.000006981641,0.001784662,0.6890548],"study_design_scores_gemma":[0.002929904,0.0006254585,0.000002956738,0.005408813,0.0006919435,0.00003112327,0.0001682655,0.0004278473,0.1961474,0.00001069509,0.7927447,0.0008109275],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02589478,0.9655437,0.0001222073,0.0001995263,0.000944766,0.005678797,0.0001592242,0.00007756436,0.001379448],"genre_scores_gemma":[0.001068669,0.9686568,0.0008441692,0.0001954174,0.001213982,0.0004142019,0.0003316645,0.0002224043,0.02705272],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7909601,"threshold_uncertainty_score":0.9996247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1004801585316933,"score_gpt":0.3376234731705562,"score_spread":0.237143314638863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}