{"id":"W2138083352","doi":"10.1085/jgp.200910253","title":"Locale and chemistry of spermine binding in the archetypal inward rectifier Kir2.1","year":2010,"lang":"en","type":"article","venue":"The Journal of General Physiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Heart, Lung, and Blood Institute","keywords":"Spermine; Chemistry; Biophysics; Allosteric regulation; Polyamine; Stereochemistry; Binding site; Potassium channel; Biochemistry; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001151415,0.0001850697,0.0001647217,0.00005840333,0.0001365276,0.000312064,0.0002281864,0.0002635017,0.0008178502],"category_scores_gemma":[0.0001934917,0.000128295,0.0001279595,0.00006343931,0.0002668732,0.0002552728,0.0001357496,0.0004448869,0.000329835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003818361,"about_ca_system_score_gemma":0.000170873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008440373,"about_ca_topic_score_gemma":0.001230719,"domain_scores_codex":[0.9998796,0.00001817151,0.000009311829,0.00003094866,0.0000390372,0.00002284487],"domain_scores_gemma":[0.9998871,0.00001890236,0.00004897234,0.000009730692,0.00001361044,0.00002162529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007424712,0.000005552064,0.0001280066,0.00001425953,0.000002501163,0.00003123901,0.00001112619,0.0001167595,0.9990959,0.0001209679,0.00000802771,0.0003914332],"study_design_scores_gemma":[0.000009809588,0.0001252211,0.002042365,0.000002077865,0.000005335299,0.00009844598,0.00001060531,0.0007738235,0.9963467,0.0000373745,0.0005437683,0.000004418666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958995,0.0004866318,0.002568203,0.00004731899,0.000007513224,0.000007935879,0.00006767779,0.00003916117,0.0008761164],"genre_scores_gemma":[0.9971396,0.0002440522,0.001445771,0.00003226715,0.000003731583,0.000007094874,0.0001053056,0.00001035317,0.001011894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008440373,"threshold_uncertainty_score":0.002770483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01060173924748947,"score_gpt":0.2463792694870557,"score_spread":0.2357775302395662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}