{"id":"W2138108723","doi":"10.1177/1040638715593368","title":"Progressive accumulation of the abnormal conformer of the prion protein and spongiform encephalopathy in the obex of nonsymptomatic and symptomatic Rocky Mountain elk ( <i>Cervus elaphus nelsoni</i> ) with chronic wasting disease","year":2015,"lang":"en","type":"article","venue":"Journal of Veterinary Diagnostic Investigation","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Food Inspection Agency","funders":"National Park Service","keywords":"Chronic wasting disease; Pathology; Transmissible spongiform encephalopathy; Biology; Anatomy; Bovine spongiform encephalopathy; Scrapie; Medicine; Disease; Prion protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005877394,0.0001199661,0.0001672232,0.00004752611,0.00006295049,0.00001884658,0.0001968461,0.0000512207,0.000001197766],"category_scores_gemma":[0.001026478,0.00006399498,0.00005378663,0.0001509681,0.0002541885,0.00004808218,0.00009738624,0.00009971893,4.421334e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000310085,"about_ca_system_score_gemma":0.0003808456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001237932,"about_ca_topic_score_gemma":0.000005310554,"domain_scores_codex":[0.9987815,0.0002158408,0.000478847,0.00009766548,0.0003091989,0.0001169344],"domain_scores_gemma":[0.9984825,0.000134664,0.0009469984,0.0001854284,0.0001764401,0.0000740184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000871338,0.0001955941,0.732753,0.002412346,0.0000996747,0.00003011796,0.003154601,0.005562862,0.245884,0.000202269,0.00001400957,0.008820246],"study_design_scores_gemma":[0.002218192,0.002942535,0.923198,0.005925357,0.0002009176,0.0004564577,0.0008456456,0.005407949,0.05777525,0.0008182586,0.00002146867,0.0001899462],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939159,0.005009432,0.00009760179,0.0001877326,0.00003482843,0.0007384509,0.00001011964,0.000001167558,0.000004807461],"genre_scores_gemma":[0.9994488,0.0001643062,0.000258327,0.00003801312,0.00004695195,0.00002902164,0.000005407642,0.000008057743,0.000001117837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1904451,"threshold_uncertainty_score":0.2609639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02514178388711908,"score_gpt":0.2721301558021422,"score_spread":0.2469883719150232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}