{"id":"W2138117999","doi":"10.1152/ajprenal.00136.2011","title":"SREBP-1 activation by glucose mediates TGF-β upregulation in mesangial cells","year":2011,"lang":"en","type":"article","venue":"American Journal of Physiology-Renal Physiology","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Sterol regulatory element-binding protein; Downregulation and upregulation; Chromatin immunoprecipitation; Diabetic nephropathy; Internal medicine; Endocrinology; Chemistry; Molecular biology; Transcription factor; Biology; Medicine; Kidney; Sterol; Biochemistry; Gene expression; Promoter; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001511179,0.0004278113,0.0003498341,0.000404825,0.0002754689,0.0003228056,0.0001551793,0.000191777,0.001292498],"category_scores_gemma":[0.00005921555,0.000172901,0.0004087392,0.0003078023,0.0001409477,0.0002044478,0.0002639475,0.0007680473,0.0007918695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000212306,"about_ca_system_score_gemma":0.0001842299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00143235,"about_ca_topic_score_gemma":0.002125058,"domain_scores_codex":[0.9998589,0.00001717864,0.00001202773,0.00002197194,0.00005010637,0.00003986747],"domain_scores_gemma":[0.9999416,0.000004723566,0.00001174498,0.000008378069,0.00001314099,0.00002034403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001415859,0.00004995989,0.0003861251,0.00005608695,0.000005917613,0.0001575329,0.00002846417,0.0000242823,0.9969864,0.00006882187,0.0001338872,0.001960834],"study_design_scores_gemma":[0.00005545027,0.0002421356,0.03267852,0.00001605087,0.00005620243,0.0004422642,0.0001219353,0.001390925,0.9578245,0.0001530885,0.007005895,0.0000130642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853199,0.005597436,0.003729774,0.0003645409,0.0001314105,0.0000453239,0.0009803323,0.0002456926,0.003585609],"genre_scores_gemma":[0.9899464,0.003119364,0.001808478,0.000143704,0.00004636175,0.00005210037,0.0009084833,0.00001934987,0.003955714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00143235,"threshold_uncertainty_score":0.00432384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01098790253059184,"score_gpt":0.2379929987340692,"score_spread":0.2270050962034774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}