{"id":"W2138129058","doi":"10.1093/toxsci/kfu068","title":"Aryl Hydrocarbon Receptor (AhR) Attenuation of Subchronic Cigarette Smoke-induced Pulmonary Neutrophilia Is Associated with Retention of Nuclear RelB and Suppression of Intercellular Adhesion Molecule-1 (ICAM-1)","year":2014,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Christie (Canada); McGill University Health Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Aryl hydrocarbon receptor; RELB; Neutrophilia; Inflammation; Chemistry; Intercellular Adhesion Molecule-1; Immunology; Lung; Medicine; Pharmacology; Internal medicine; NFKB1; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009809044,0.0001320568,0.0003363093,0.0001277315,0.0001324809,0.000007320122,0.0002163688,0.0003139928,0.0001817343],"category_scores_gemma":[0.0003132721,0.00008902683,0.00007096148,0.0003175442,0.0006457833,0.0001617967,0.00008057659,0.0001677885,0.000004698416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003163371,"about_ca_system_score_gemma":0.00003048032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002926773,"about_ca_topic_score_gemma":0.000001734318,"domain_scores_codex":[0.9984822,0.0004338073,0.0004445448,0.0002968423,0.0001342254,0.0002083268],"domain_scores_gemma":[0.9989883,0.0002083212,0.0005222411,0.0001606458,0.0001011642,0.00001927238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004700856,0.0001247105,0.002643274,0.00002432958,0.00002594214,8.04126e-7,0.0001995062,0.000007448537,0.9944426,0.0002459878,0.00004874124,0.001766517],"study_design_scores_gemma":[0.0005140233,0.003652729,0.089384,0.0003177491,0.00003785451,0.000006329064,0.0001127404,0.0006917604,0.9049204,0.0002092112,0.00004231346,0.0001108965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986018,0.0003364755,0.00001268966,0.0003499867,0.00009373462,0.0002059163,0.000003482199,0.00002182844,0.0003741042],"genre_scores_gemma":[0.9997101,0.000144668,0.00002050277,0.00003503041,0.00000681169,0.000004611154,0.00003346551,0.000005766143,0.00003899158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08952226,"threshold_uncertainty_score":0.3630409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02373739927003143,"score_gpt":0.2344713019486196,"score_spread":0.2107339026785882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}