{"id":"W2138129058","doi":"10.1093/toxsci/kfu068","title":"Aryl Hydrocarbon Receptor (AhR) Attenuation of Subchronic Cigarette Smoke-induced Pulmonary Neutrophilia Is Associated with Retention of Nuclear RelB and Suppression of Intercellular Adhesion Molecule-1 (ICAM-1)","year":2014,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Christie (Canada); McGill University Health Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Aryl hydrocarbon receptor; RELB; Neutrophilia; Inflammation; Chemistry; Intercellular Adhesion Molecule-1; Immunology; Lung; Medicine; Pharmacology; Internal medicine; NFKB1; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002008662,0.0004583524,0.0003683594,0.0002955573,0.0001332056,0.0002059442,0.0002340242,0.0003682942,0.001660094],"category_scores_gemma":[0.00007364406,0.0001636394,0.0004161214,0.0001611163,0.000401406,0.00018248,0.0002608703,0.001063744,0.0003667823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000202838,"about_ca_system_score_gemma":0.0002218638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006085922,"about_ca_topic_score_gemma":0.001351245,"domain_scores_codex":[0.9996856,0.00004789403,0.0000279626,0.00005869096,0.00008736691,0.00009245658],"domain_scores_gemma":[0.9998376,0.00001355411,0.00004845436,0.00002131029,0.00001643132,0.00006250638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001097853,0.00006057455,0.00007053796,0.00001914516,0.000002442833,0.00002076927,0.000006413779,0.00001078253,0.9993079,0.00002231544,0.00001340488,0.000355955],"study_design_scores_gemma":[0.00003945538,0.001939251,0.01027529,0.00000800796,0.00001456696,0.0001878131,0.00003649854,0.0002498048,0.9864067,0.00003396582,0.0008036789,0.000004921249],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953056,0.00166326,0.001606584,0.0001024793,0.00004862254,0.00005138023,0.0003508141,0.00009443441,0.0007767708],"genre_scores_gemma":[0.992092,0.001235022,0.001751192,0.0000835743,0.00002055083,0.0001026942,0.0005370901,0.00002098626,0.004156833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001660094,"threshold_uncertainty_score":0.005553603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02373739927003143,"score_gpt":0.2344713019486196,"score_spread":0.2107339026785882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}