{"id":"W2138153828","doi":"10.1002/bdd.1931","title":"The guinea‐pig expresses functional CYP2C and P‐glycoprotein: further validation of its usefulness in drug biotransformation/transport studies","year":2014,"lang":"en","type":"article","venue":"Biopharmaceutics & Drug Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"","keywords":"Guinea pig; Biology; P-glycoprotein; Transfection; Pharmacology; Molecular biology; Biochemistry; Gene; Multiple drug resistance; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009509887,0.0005506974,0.000335791,0.0004196443,0.0001875551,0.0004129701,0.0003568794,0.0006509028,0.002478368],"category_scores_gemma":[0.0005906305,0.0001869768,0.0005010128,0.0002902798,0.000443715,0.0003705038,0.0002059854,0.0009121535,0.0009670006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002533275,"about_ca_system_score_gemma":0.0002040424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006587646,"about_ca_topic_score_gemma":0.0006460133,"domain_scores_codex":[0.999706,0.0001009201,0.00002788854,0.00006559707,0.00005342167,0.00004620783],"domain_scores_gemma":[0.9993538,0.0002014219,0.0001027331,0.0001652064,0.0001148059,0.00006200834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001516055,0.0001127452,0.0003311737,0.00006615256,0.00001596544,0.0001532468,0.00002089506,0.00002709683,0.9973918,0.0001402662,0.00009362651,0.001495385],"study_design_scores_gemma":[0.0001273328,0.003545759,0.01336566,0.00004165256,0.0002045955,0.0022752,0.00007194898,0.001009333,0.9640703,0.0001128815,0.01515859,0.0000168683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9547563,0.004335831,0.03182017,0.0007771797,0.0003074188,0.0005065029,0.002327669,0.0002508644,0.004918074],"genre_scores_gemma":[0.944638,0.004609067,0.03790144,0.0003308083,0.0001029494,0.000442313,0.00589677,0.0002222342,0.00585653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002478368,"threshold_uncertainty_score":0.008290946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08987003790453561,"score_gpt":0.3904237972304724,"score_spread":0.3005537593259368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}