{"id":"W2138167941","doi":"10.1097/ccm.0b013e3181b07b78","title":"Phase 2 trial of eritoran tetrasodium (E5564), a Toll-like receptor 4 antagonist, in patients with severe sepsis*","year":2009,"lang":"en","type":"article","venue":"Critical Care Medicine","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":226,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eisai","keywords":"Medicine; Placebo; Internal medicine; Sepsis; Tolerability; Proinflammatory cytokine; Immunology; Adverse effect; Gastroenterology; Inflammation; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001783845,0.001893681,0.001972421,0.0002818067,0.0003447664,0.0007950015,0.0005890864,0.001221654,0.003759528],"category_scores_gemma":[0.001260677,0.0006413803,0.001140044,0.0002436948,0.0007278495,0.0006696839,0.0002738389,0.002290973,0.0006381092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005911948,"about_ca_system_score_gemma":0.001533976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000970288,"about_ca_topic_score_gemma":0.001522563,"domain_scores_codex":[0.9995364,0.0002492175,0.00002552214,0.00007442033,0.00003012116,0.00008439089],"domain_scores_gemma":[0.9992255,0.0001624514,0.0001579956,0.00006644124,0.00007670523,0.0003108882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9597737,0.01667586,0.00168121,0.0002309478,0.0004008587,0.00005599938,0.00005383297,0.0004151981,0.006570459,0.00007366246,0.0009121443,0.01315612],"study_design_scores_gemma":[0.8661399,0.1300607,0.00232438,0.00001153556,0.0001291433,0.00003317194,0.00001441348,0.0003124966,0.0005150983,0.00004812824,0.0004016993,0.000009224173],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992276,0.001162903,0.0005060623,0.0005013126,0.0002051243,0.003497856,0.0007328808,0.00006526826,0.001052706],"genre_scores_gemma":[0.9860244,0.001319326,0.001789104,0.001400988,0.0003607952,0.004921492,0.001689181,0.00001906681,0.002475554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003759528,"threshold_uncertainty_score":0.01257688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009388701819016675,"score_gpt":0.284480393267328,"score_spread":0.2750916914483113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}