{"id":"W2138175677","doi":"10.2337/db13-1398","title":"Fluvastatin Causes NLRP3 Inflammasome-Mediated Adipose Insulin Resistance","year":2014,"lang":"en","type":"article","venue":"Diabetes","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Inflammasome; Insulin resistance; Fluvastatin; Internal medicine; Endocrinology; Adipose tissue; Medicine; Statin; Type 2 diabetes; Caspase 1; Diabetes mellitus; Insulin; Inflammation; Simvastatin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002288082,0.0002020565,0.0001861367,0.00005858914,0.0001060504,0.00003668735,0.0002280848,0.0001422883,0.00004769272],"category_scores_gemma":[0.0005877826,0.000198075,0.00008815637,0.0001326363,0.0001094793,0.000008346044,0.00008457099,0.0001036121,0.0001544238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007947731,"about_ca_system_score_gemma":0.00004481079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004706318,"about_ca_topic_score_gemma":0.00004888992,"domain_scores_codex":[0.9987764,0.00009990008,0.0002598033,0.0003263713,0.000128173,0.0004092886],"domain_scores_gemma":[0.9992466,0.00004998971,0.00009778988,0.0004276279,0.0001012652,0.00007671671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004929302,0.00004903695,0.01913398,0.00004704686,0.00008658674,0.000001104394,0.0001108135,0.00002135971,0.9700076,0.000212694,0.006353107,0.003927397],"study_design_scores_gemma":[0.0008319772,0.0001579215,0.0152495,0.00002660808,0.00001846689,2.206428e-7,0.0000592654,0.00005026885,0.6632143,0.0002166877,0.3198367,0.0003380936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925457,0.002427058,0.00005083823,0.0001961227,0.0001516491,0.0001361246,0.00002508619,0.00003956712,0.004427843],"genre_scores_gemma":[0.9964408,0.0001865956,0.000292356,0.0007390607,0.0001827482,0.00004616819,0.0004976419,0.00003766594,0.00157699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3134836,"threshold_uncertainty_score":0.8077264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003939580359196584,"score_gpt":0.1998536834877823,"score_spread":0.1959141031285857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}