{"id":"W2138175677","doi":"10.2337/db13-1398","title":"Fluvastatin Causes NLRP3 Inflammasome-Mediated Adipose Insulin Resistance","year":2014,"lang":"en","type":"article","venue":"Diabetes","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Inflammasome; Insulin resistance; Fluvastatin; Internal medicine; Endocrinology; Adipose tissue; Medicine; Statin; Type 2 diabetes; Caspase 1; Diabetes mellitus; Insulin; Inflammation; Simvastatin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001992967,0.0004302982,0.0005387705,0.0003203331,0.0002176243,0.0001615196,0.0001846792,0.0004782052,0.001775367],"category_scores_gemma":[0.000192825,0.0001824364,0.0005873608,0.0002823149,0.0002356246,0.0001708612,0.0002508795,0.0005674961,0.000316675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003012125,"about_ca_system_score_gemma":0.0002765613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008811724,"about_ca_topic_score_gemma":0.0008900957,"domain_scores_codex":[0.9997675,0.00004657871,0.00003142342,0.00003377162,0.00004213103,0.0000785046],"domain_scores_gemma":[0.9998811,0.00001889541,0.00003733372,0.00001619722,0.00001290004,0.00003352384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001908308,0.0001442992,0.0008892799,0.0001352046,0.00004510667,0.0004826816,0.0000271559,0.00006678532,0.9921469,0.0001563375,0.0002736856,0.003724386],"study_design_scores_gemma":[0.0006944768,0.005533909,0.02244146,0.00003506447,0.0001759206,0.004174973,0.00007949223,0.001600721,0.9569566,0.0003526674,0.007930312,0.00002445001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883848,0.004608438,0.003550927,0.0005524026,0.0001264682,0.0000923519,0.0005533427,0.0003026583,0.00182849],"genre_scores_gemma":[0.9957007,0.001372246,0.0008375344,0.0002229839,0.00002533689,0.00005161549,0.0004561082,0.00001997739,0.001313531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001775367,"threshold_uncertainty_score":0.005939126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003939580359196584,"score_gpt":0.1998536834877823,"score_spread":0.1959141031285857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}