{"id":"W2138182618","doi":"10.1523/jneurosci.5123-04.2005","title":"ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75<sup>NTR</sup>and Sortilin","year":2005,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":993,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Lundbeckfonden; H. Lundbeck A/S; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Medical Research Council; Novo Nordisk; Sundhed og Sygdom, Det Frie Forskningsråd; Burroughs Wellcome Fund","keywords":"Tropomyosin receptor kinase B; Low-affinity nerve growth factor receptor; Neurotrophin; Neurotrophic factors; Cell biology; Receptor; Programmed cell death; Biology; Brain-derived neurotrophic factor; Tropomyosin receptor kinase A; Nerve growth factor; Neuroscience; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001283098,0.0003602471,0.0003012958,0.000206764,0.000166051,0.0001896183,0.0002421749,0.000261076,0.001061723],"category_scores_gemma":[0.0001517442,0.0001322423,0.00029267,0.0001233128,0.0001262118,0.0001560447,0.0001551918,0.0004642874,0.000281743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004754598,"about_ca_system_score_gemma":0.0002645189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001317313,"about_ca_topic_score_gemma":0.001767515,"domain_scores_codex":[0.9997664,0.00002215891,0.00002583642,0.00002507736,0.00008827063,0.00007223448],"domain_scores_gemma":[0.9999013,0.00002282518,0.00002137057,0.00001240988,0.0000130529,0.00002895638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002092618,0.0000814092,0.0002247793,0.00005866694,0.00001109646,0.0001637477,0.00002229413,0.00006638693,0.9976169,0.00008670412,0.00006274285,0.001396075],"study_design_scores_gemma":[0.00005574032,0.001062779,0.007865632,0.000009648886,0.00002195541,0.0008594632,0.0000444229,0.001822155,0.9859263,0.00007808747,0.002247387,0.000006399664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966204,0.001051947,0.0007897799,0.00005358181,0.000025574,0.00002405823,0.0001414898,0.00003915085,0.001254061],"genre_scores_gemma":[0.9953767,0.0008390216,0.001131254,0.00005502089,0.00001427393,0.00005468234,0.0005853629,0.000007490626,0.001936114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001317313,"threshold_uncertainty_score":0.003551841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06237428693103431,"score_gpt":0.2964300286079844,"score_spread":0.2340557416769501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}