{"id":"W2138182618","doi":"10.1523/jneurosci.5123-04.2005","title":"ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75<sup>NTR</sup>and Sortilin","year":2005,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":993,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Lundbeckfonden; H. Lundbeck A/S; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Medical Research Council; Novo Nordisk; Sundhed og Sygdom, Det Frie Forskningsråd; Burroughs Wellcome Fund","keywords":"Tropomyosin receptor kinase B; Low-affinity nerve growth factor receptor; Neurotrophin; Neurotrophic factors; Cell biology; Receptor; Programmed cell death; Biology; Brain-derived neurotrophic factor; Tropomyosin receptor kinase A; Nerve growth factor; Neuroscience; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004131544,0.0001431091,0.0002810845,0.0002556471,0.0001546304,0.00004584473,0.0004047031,0.00005727082,0.00002448033],"category_scores_gemma":[0.0008349959,0.000113338,0.00009752672,0.0005576565,0.0004565281,0.0009944956,0.0000751145,0.0002607307,0.000001595063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002254641,"about_ca_system_score_gemma":0.0001099337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003017685,"about_ca_topic_score_gemma":4.658858e-7,"domain_scores_codex":[0.9978015,0.0002149029,0.0007669398,0.0002899374,0.0007184354,0.0002082611],"domain_scores_gemma":[0.9983516,0.0001940013,0.001000445,0.0001634188,0.0001734994,0.0001170881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001022815,0.0002106284,0.0002122679,0.00002141753,0.000001148121,9.518786e-7,0.0002135018,0.002917118,0.9904886,0.0002191408,0.0001346747,0.005478285],"study_design_scores_gemma":[0.0003362137,0.0006598059,0.006433524,0.00004405116,0.000009869468,0.00007237219,0.0000207203,0.008079005,0.9834388,0.0001017565,0.0007086421,0.00009524287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969348,0.00001139667,0.001028397,0.001549118,0.0002355311,0.0001452617,0.000008787442,0.000008638289,0.00007803157],"genre_scores_gemma":[0.9980437,0.00006393437,0.00105635,0.0005756828,0.0001733598,0.000001834461,3.434464e-7,0.0000103657,0.00007439363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007049788,"threshold_uncertainty_score":0.4621789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06237428693103431,"score_gpt":0.2964300286079844,"score_spread":0.2340557416769501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}