{"id":"W2138199798","doi":"10.1161/01.hyp.35.1.38","title":"G-Protein–Coupled Receptor Kinase Activity in Hypertension","year":2000,"lang":"en","type":"article","venue":"Hypertension","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"National Institute of General Medical Sciences; American Heart Association; Medical Research Council; National Institutes of Health; Medical Research Council Canada; Heart and Stroke Foundation of Canada","keywords":"Internal medicine; Endocrinology; Medicine; Vascular smooth muscle; Receptor; Lymphocyte; Adenylyl cyclase; Vasodilation; G protein; Protein kinase A; Kinase; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002107571,0.0002045884,0.0002360973,0.00005788821,0.00009950687,0.00002112733,0.0001275949,0.000245464,0.0008293604],"category_scores_gemma":[0.00005365574,0.0001797575,0.00010281,0.0001357476,0.00003162483,0.000009013003,0.00005138332,0.0001475742,0.0001593414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001949925,"about_ca_system_score_gemma":0.00003615025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001681744,"about_ca_topic_score_gemma":0.00002774967,"domain_scores_codex":[0.9987158,0.00008695693,0.0001966939,0.000495897,0.0001791831,0.0003254383],"domain_scores_gemma":[0.9993956,0.000009096902,0.00004351626,0.0003790662,0.00006832344,0.0001043872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002775326,0.0001308401,0.00005368554,0.000007237854,0.000007634767,0.00002160545,0.000009860436,0.00007613828,0.9733195,0.000009777214,0.0008107373,0.02527543],"study_design_scores_gemma":[0.00110732,0.0003016797,0.0008562355,0.00007128576,0.00000916226,0.0000368033,0.00002616252,0.003478964,0.970448,0.0000502413,0.02329308,0.0003210253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982878,0.0004131632,0.0001709179,0.0001851052,0.0001613645,0.000253322,0.000003704624,0.00002759313,0.0004970554],"genre_scores_gemma":[0.9965629,0.0003151773,0.001125041,0.0004607776,0.0001957793,0.00002214877,0.00005786146,0.00003631305,0.001224028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02495441,"threshold_uncertainty_score":0.9080914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01575986262669718,"score_gpt":0.2152431458723433,"score_spread":0.1994832832456461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}