{"id":"W2138199798","doi":"10.1161/01.hyp.35.1.38","title":"G-Protein–Coupled Receptor Kinase Activity in Hypertension","year":2000,"lang":"en","type":"article","venue":"Hypertension","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"National Institute of General Medical Sciences; American Heart Association; Medical Research Council; National Institutes of Health; Medical Research Council Canada; Heart and Stroke Foundation of Canada","keywords":"Internal medicine; Endocrinology; Medicine; Vascular smooth muscle; Receptor; Lymphocyte; Adenylyl cyclase; Vasodilation; G protein; Protein kinase A; Kinase; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001011466,0.0002235218,0.0002260657,0.0002379171,0.0001264401,0.000248506,0.0001134664,0.0002827882,0.0008574308],"category_scores_gemma":[0.00009124046,0.0000945549,0.0001872605,0.0001494198,0.000174204,0.0001421336,0.000128489,0.0004755595,0.0002824285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002182287,"about_ca_system_score_gemma":0.0001321194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007769527,"about_ca_topic_score_gemma":0.0006916423,"domain_scores_codex":[0.999945,0.00001114643,0.000003991168,0.0000110842,0.00001217427,0.00001659658],"domain_scores_gemma":[0.9999468,0.000004583923,0.00001859234,0.000004590499,0.000005043499,0.00002036753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002297313,0.0002518538,0.01588667,0.0002562255,0.00007931934,0.001969641,0.00007945577,0.00018388,0.9526587,0.0008156812,0.0007436745,0.02477759],"study_design_scores_gemma":[0.0003014492,0.001563427,0.884217,0.0000613078,0.0002850642,0.008678988,0.0001542413,0.00201296,0.08819361,0.001746867,0.0127527,0.00003250594],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9661694,0.02810504,0.001118314,0.0005847738,0.0001627321,0.00001571193,0.0002030729,0.00008575341,0.003555197],"genre_scores_gemma":[0.9895478,0.00797177,0.0003873814,0.0001368899,0.0001408146,0.000008620726,0.0002092792,0.000006227297,0.001591126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008574308,"threshold_uncertainty_score":0.002868414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01575986262669718,"score_gpt":0.2152431458723433,"score_spread":0.1994832832456461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}