{"id":"W2138202269","doi":"10.1002/prot.24285","title":"Protein misfolding in the late‐onset neurodegenerative diseases: Common themes and the unique case of amyotrophic lateral sclerosis","year":2013,"lang":"en","type":"review","venue":"Proteins Structure Function and Bioinformatics","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Amyotrophic lateral sclerosis; SOD1; Disease; Parkin; Neurodegeneration; Neuroscience; Medicine; Biology; Parkinson's disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003837098,0.0004850191,0.001283602,0.0002390027,0.0002794149,0.0001973899,0.0002039554,0.0003165346,0.00006205969],"category_scores_gemma":[0.0001373758,0.0002017304,0.0002027082,0.0004951456,0.0005845287,0.0002204614,0.0001930458,0.0009942545,0.000002737062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006127522,"about_ca_system_score_gemma":0.0001405028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002982923,"about_ca_topic_score_gemma":0.00005345961,"domain_scores_codex":[0.9974564,0.0006317119,0.0009455314,0.0002315981,0.000398775,0.000335971],"domain_scores_gemma":[0.9985249,0.0001911856,0.0005183629,0.0005133817,0.0001208209,0.0001313394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006094127,0.0001061477,0.0003022285,0.0389078,0.0004724229,0.00007416322,0.003927169,0.000005745669,0.0001155252,0.001288054,0.0001961316,0.9539952],"study_design_scores_gemma":[0.09014308,0.02112395,0.04949986,0.2725918,0.03110095,0.04900401,0.01814843,0.08155007,0.0007460671,0.03084275,0.3419091,0.01333988],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2368357,0.7468896,0.00008380439,0.0008768717,0.00009904256,0.01474482,0.0003483384,0.00004999142,0.00007187066],"genre_scores_gemma":[0.1719773,0.8255658,0.0008435408,0.0003317044,0.0001249332,0.0008099415,0.0001822198,0.00004970818,0.0001148583],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9406553,"threshold_uncertainty_score":0.8226327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03999805314667022,"score_gpt":0.2920854822541304,"score_spread":0.2520874291074602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}