{"id":"W2138216643","doi":"10.1128/jvi.77.16.8621-8632.2003","title":"Diminished RNA Primer Usage Associated with the L74V and M184V Mutations in the Reverse Transcriptase of Human Immunodeficiency Virus Type 1 Provides a Possible Mechanism for Diminished Viral Replication Capacity","year":2003,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Bristol-Myers Squibb","keywords":"Biology; Reverse transcriptase; Resistance mutation; Virology; Primer (cosmetics); Viral replication; Mutant; Virus; Mutation; DNA; RNA; Molecular biology; Genetics; Gene; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003114987,0.0003958379,0.0003447653,0.0002776328,0.0001325252,0.0003697468,0.0003126108,0.0004970017,0.0008005095],"category_scores_gemma":[0.0004471375,0.0002843495,0.0003385422,0.00016019,0.0002943739,0.0002675004,0.0001687853,0.0005007772,0.000316265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003039096,"about_ca_system_score_gemma":0.0001905661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002249189,"about_ca_topic_score_gemma":0.0004110223,"domain_scores_codex":[0.9996257,0.0001061357,0.00004170613,0.00006913369,0.0001080364,0.00004928319],"domain_scores_gemma":[0.9996252,0.0001229947,0.0001541403,0.00003324375,0.00003450519,0.00002973852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006207469,0.00002977956,0.001197181,0.00002282925,0.000008994728,0.000111465,0.0000151142,0.0001337458,0.9968938,0.0001069397,0.00001420717,0.001403803],"study_design_scores_gemma":[0.000009795514,0.0004976953,0.004028553,0.000003808807,0.00002156229,0.0007876192,0.00001464134,0.0008756238,0.9930043,0.00006949854,0.0006803775,0.000006647696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975016,0.0004372314,0.00165231,0.0000304624,0.00000791358,0.00001606513,0.00008210952,0.00003039081,0.0002419246],"genre_scores_gemma":[0.9945164,0.0002379796,0.004409477,0.00002844417,0.000006976696,0.0000238918,0.000259222,0.00001390123,0.0005035908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008005095,"threshold_uncertainty_score":0.002677977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03286918346993,"score_gpt":0.2878247390146312,"score_spread":0.2549555555447012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}