{"id":"W2138219103","doi":"10.2174/138161212803523617","title":"Genetics and Personalized Medicine in Antidepressant Treatment","year":2012,"lang":"en","type":"review","venue":"Current Pharmaceutical Design","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research; National Alliance for Research on Schizophrenia and Depression","keywords":"Pharmacogenetics; Serotonin transporter; Antidepressant; Medicine; Pharmacogenomics; Personalized medicine; Candidate gene; Pharmacodynamics; Drug; Pharmacology; Anxiety; Precision medicine; Bioinformatics; Psychiatry; Gene; Genetics; Pharmacokinetics; Internal medicine; Biology; Genotype; Serotonin; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005036364,0.0005163205,0.001293598,0.001583374,0.0005241887,0.002073541,0.0007651818,0.002357313,0.006116972],"category_scores_gemma":[0.009961725,0.0001947468,0.0008878197,0.001542867,0.001934592,0.00139917,0.001332665,0.003064247,0.001010314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001783216,"about_ca_system_score_gemma":0.002948386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002003814,"about_ca_topic_score_gemma":0.002783572,"domain_scores_codex":[0.9970003,0.00213448,0.0001282315,0.0002953273,0.0003584676,0.00008320807],"domain_scores_gemma":[0.9927079,0.005894129,0.0004038984,0.0002732696,0.0004682929,0.0002525376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001616314,0.0001162091,0.01315499,0.005146293,0.00116885,0.0009036898,0.001088679,0.00250599,0.000976728,0.09652345,0.1003079,0.7779455],"study_design_scores_gemma":[0.0001669772,0.000209786,0.01801946,0.008689743,0.0008576746,0.002576422,0.0009506453,0.002259329,0.0006518566,0.4717353,0.493759,0.0001237524],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006349716,0.6172043,0.02460783,0.3232001,0.004027251,0.0001129263,0.0009565487,0.0003039637,0.02323725],"genre_scores_gemma":[0.1453731,0.7335505,0.04560116,0.05968307,0.009631925,0.0003494904,0.000995955,0.00008690698,0.004727773],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006116972,"threshold_uncertainty_score":0.02663517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4980078758323496,"score_gpt":0.4936514360827158,"score_spread":0.004356439749633789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}