{"id":"W2138226209","doi":"10.1093/ndt/gfp020","title":"Proteomic analysis of urine from proteinuric patients shows a proteolitic activity directed against albumin","year":2009,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Albumin; Medicine; Nephrotic syndrome; Proteinuria; Urine; Chromatography; Urinary system; Proteolytic enzymes; Trichloroacetic acid; Internal medicine; Biochemistry; Chemistry; Kidney; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001159439,0.0002467874,0.000850117,0.0006788894,0.00006632943,0.00001162205,0.00008935317,0.0001853579,0.0001244484],"category_scores_gemma":[0.00005816644,0.0002131037,0.0004427882,0.001207528,0.00009260584,0.000140514,0.000005693431,0.000167983,0.00000902923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005619096,"about_ca_system_score_gemma":0.00007385463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003420731,"about_ca_topic_score_gemma":0.0001307963,"domain_scores_codex":[0.9981734,0.000225643,0.0004884548,0.0004533377,0.0003672447,0.0002919862],"domain_scores_gemma":[0.9989718,0.0000685359,0.0002792065,0.0003370876,0.0001991477,0.0001442351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007766487,0.002547079,0.3002437,0.0003144813,0.004454645,0.00007705441,0.001388009,0.0005174307,0.6510102,0.00002357537,0.00002930271,0.03162801],"study_design_scores_gemma":[0.002504761,0.0005507666,0.9504868,0.0000580953,0.009969178,0.00000108745,0.000005842509,0.002734934,0.03340683,0.0001006968,0.00001249715,0.0001684924],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967657,0.00007381207,0.0006664527,0.000262983,0.00002488509,0.001527307,0.0003486359,0.0001114134,0.0002187714],"genre_scores_gemma":[0.9963841,0.0001840179,0.0005726613,0.0004305715,0.00004952988,0.0001948936,0.002129479,0.00001400682,0.00004076185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.650243,"threshold_uncertainty_score":0.8690115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007247600871095633,"score_gpt":0.2399432081825159,"score_spread":0.2326956073114202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}