{"id":"W2138229302","doi":"10.1093/hmg/ddp358","title":"Evaluation of the therapeutic potential of carbonic anhydrase inhibitors in two animal models of dystrophin deficient muscular dystrophy","year":2009,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Dystrophin; Duchenne muscular dystrophy; Muscular dystrophy; Biology; Carbonic anhydrase; mdx mouse; Diaphragm (acoustics); Isometric exercise; Pharmacology; Anatomy; Endocrinology; Internal medicine; Biochemistry; Medicine; Enzyme; Genetics; Physiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002636993,0.0008108218,0.0007598053,0.0008162775,0.0002473833,0.0003154998,0.0003934068,0.0007209153,0.001028331],"category_scores_gemma":[0.0001865446,0.0002199425,0.0004460193,0.0003138192,0.0002328637,0.0002646405,0.0002034834,0.000884431,0.0001579276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004427067,"about_ca_system_score_gemma":0.000363479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001210436,"about_ca_topic_score_gemma":0.00387927,"domain_scores_codex":[0.9997906,0.00003007899,0.00002200722,0.00004132963,0.00007481931,0.00004110016],"domain_scores_gemma":[0.9997928,0.00003261447,0.00005183399,0.00001218379,0.00003805766,0.00007263893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000219059,0.0002234296,0.0001858254,0.00008470417,0.00001991271,0.00006945019,0.0000113658,0.0001373937,0.9977033,0.0000309807,0.00006127988,0.0012534],"study_design_scores_gemma":[0.0001985205,0.01367794,0.008304091,0.00003414381,0.0002168646,0.0003671779,0.00006265968,0.001311154,0.9725185,0.00004482165,0.003238986,0.00002521105],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926513,0.002642839,0.001706321,0.0001944799,0.00006055179,0.0002517838,0.001120398,0.0001138224,0.001258504],"genre_scores_gemma":[0.9787635,0.005419752,0.007232037,0.0001775966,0.00002272733,0.0003966113,0.002854038,0.00003517018,0.005098616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001210436,"threshold_uncertainty_score":0.003440082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01671054289216906,"score_gpt":0.2745468791200516,"score_spread":0.2578363362278825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}