{"id":"W2138230377","doi":"10.4049/jimmunol.1401605","title":"TRAM Is Required for TLR2 Endosomal Signaling to Type I IFN Induction","year":2014,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Wellcome Trust","keywords":"Endosome; Cell biology; TLR2; Chemistry; Signal transduction; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001341367,0.0001256871,0.0002935723,0.0001926913,0.000221795,0.00001062716,0.0003437174,0.0002231249,0.0001809929],"category_scores_gemma":[0.0005298192,0.00008528607,0.00011493,0.0001436322,0.0001141008,0.0001408914,0.00004259562,0.0003261786,0.0002356598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000439229,"about_ca_system_score_gemma":0.00007757339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001494054,"about_ca_topic_score_gemma":0.000001665972,"domain_scores_codex":[0.9985327,0.0005346875,0.0005276016,0.00008923225,0.00003624731,0.0002795506],"domain_scores_gemma":[0.9985823,0.000465954,0.0003976719,0.0002292002,0.0003116436,0.00001322795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003382186,0.00003200274,0.00001217076,0.000004598074,0.0002625275,4.382401e-7,0.001618735,0.00003663213,0.9674293,0.0005486701,0.00269876,0.02397397],"study_design_scores_gemma":[0.001535179,0.002388682,0.001040846,0.00003737377,0.0001035225,0.0006053762,0.0005847038,0.000007297542,0.8666962,0.0008367863,0.1260546,0.000109406],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873238,0.002040213,0.004725785,0.003349834,0.002161882,0.0002075192,0.000001652855,0.00001662226,0.0001726685],"genre_scores_gemma":[0.9979321,0.0001197144,0.0002703099,0.000470959,0.000180458,0.000004608336,0.000006576838,0.00001547766,0.0009998347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1233558,"threshold_uncertainty_score":0.3477865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01983958843351726,"score_gpt":0.2577133236561203,"score_spread":0.237873735222603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}