{"id":"W2138230377","doi":"10.4049/jimmunol.1401605","title":"TRAM Is Required for TLR2 Endosomal Signaling to Type I IFN Induction","year":2014,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Wellcome Trust","keywords":"Endosome; Cell biology; TLR2; Chemistry; Signal transduction; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001774258,0.0004158975,0.0002850091,0.000338441,0.0003754551,0.0004345936,0.0003526302,0.0005041562,0.002367218],"category_scores_gemma":[0.0002698411,0.0002774516,0.0006653256,0.0001602332,0.0002048979,0.0002673928,0.0005337335,0.000792139,0.002032122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006278759,"about_ca_system_score_gemma":0.0004127383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001219918,"about_ca_topic_score_gemma":0.001320908,"domain_scores_codex":[0.9997203,0.00003897793,0.00002743931,0.00005593415,0.00006817583,0.00008917425],"domain_scores_gemma":[0.9996477,0.00003703793,0.0001377426,0.0000546066,0.00003718428,0.00008569843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001052427,0.00001483992,0.0003049009,0.00003398583,0.00000555434,0.0001033931,0.00001330823,0.00002925245,0.9987537,0.00007940659,0.000054617,0.0005017827],"study_design_scores_gemma":[0.00002781449,0.0001565818,0.02483454,0.00002345384,0.00002533403,0.001336768,0.0001126673,0.001745928,0.9637992,0.00009293779,0.007825535,0.00001927405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908399,0.002416874,0.003473005,0.0002101426,0.00008475763,0.00002927847,0.001155665,0.0001524912,0.001637848],"genre_scores_gemma":[0.9897172,0.0005875251,0.00268282,0.0001198688,0.00002024569,0.00004637286,0.002568768,0.00006344703,0.004193556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002367218,"threshold_uncertainty_score":0.007919192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01983958843351726,"score_gpt":0.2577133236561203,"score_spread":0.237873735222603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}