{"id":"W2138232488","doi":"10.2174/13816128113199990538","title":"Utility of MLH1 Methylation Analysis in the Clinical Evaluation of Lynch Syndrome in Women with Endometrial Cancer","year":2014,"lang":"en","type":"article","venue":"Current Pharmaceutical Design","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Cancer Institute","keywords":"Lynch syndrome; MLH1; Microsatellite instability; Endometrial cancer; Medicine; DNA methylation; Oncology; Cancer research; Cancer; DNA mismatch repair; Internal medicine; Pathology; Biology; Genetics; Microsatellite; Gene; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01086082,0.0001359788,0.0006282241,0.0004174869,0.00001230981,0.000005184812,0.0001585305,0.00008797189,0.000581542],"category_scores_gemma":[0.001828625,0.00008884937,0.0001044255,0.002187507,0.000203429,0.00004258072,0.00002449474,0.0003857344,0.000001651418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001650467,"about_ca_system_score_gemma":0.0003343367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002619059,"about_ca_topic_score_gemma":0.00002006935,"domain_scores_codex":[0.9951237,0.002401317,0.0008118804,0.0003150627,0.001099588,0.0002484027],"domain_scores_gemma":[0.9972938,0.001820665,0.0002086843,0.0002938971,0.0002829303,0.00009998829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005660138,0.001193365,0.5003906,0.0001925673,0.0004170189,0.000001757423,0.0006294318,0.002953798,0.001319494,0.000032021,0.00004468683,0.4871651],"study_design_scores_gemma":[0.006463773,0.0007991936,0.8246394,0.000086223,0.001541891,0.000001696853,0.00004482086,0.1620509,0.003868798,0.0002680654,0.000142798,0.00009234772],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884788,0.001036814,0.008696145,0.0001295807,0.0002759903,0.001238274,0.000007706136,0.000005963559,0.0001307244],"genre_scores_gemma":[0.9991806,0.0001870514,0.0003411145,0.00004242846,0.00005474452,0.000178975,0.000005996948,0.000007863197,0.000001181849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4870727,"threshold_uncertainty_score":0.6367477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3045770330178338,"score_gpt":0.5031906984942208,"score_spread":0.198613665476387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}