{"id":"W2138254488","doi":"10.1110/ps.9.5.991","title":"Penicillopepsin‐JT2, a recombinant enzyme from <i>Penicillium janthinellum</i> and the contribution of a hydrogen bond in subsite S<sub>3</sub> to k<sub><i>cat</i></sub>","year":2000,"lang":"en","type":"article","venue":"Protein Science","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Biochemistry; Peptide sequence; Aspergillus awamori; Stereochemistry; Chemistry; Amino acid; Biology; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001245193,0.0001821653,0.0002333648,0.00008272372,0.0001800033,0.00006524967,0.0003598025,0.0001032908,0.00001237022],"category_scores_gemma":[0.0002898215,0.0001455046,0.000056976,0.0006155101,0.0005369093,0.0000389024,0.0001524976,0.0001088109,0.00002141832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003591159,"about_ca_system_score_gemma":0.0001557761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000123534,"about_ca_topic_score_gemma":0.0001708226,"domain_scores_codex":[0.9981358,0.0001189561,0.0004257569,0.0006501951,0.0003197955,0.0003494649],"domain_scores_gemma":[0.999056,0.00001666909,0.000165623,0.0004599487,0.000183758,0.000117956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003501177,0.0000609793,0.0004277841,0.000005805286,0.000006267172,0.000001133341,0.0002354474,0.00002425926,0.9939486,0.0001018836,0.00005139808,0.004786271],"study_design_scores_gemma":[0.001180711,0.0001239866,0.002096222,0.00004744848,0.00001090322,0.00001034265,0.00003022584,0.0003210276,0.9943211,0.0003157428,0.001350964,0.0001913384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963263,0.0006746866,0.0002723899,0.001546957,0.00009630994,0.0009457178,0.00001956381,0.0000129791,0.0001050566],"genre_scores_gemma":[0.9984272,0.0005958917,0.0001546416,0.000512325,0.00007435203,0.0001075202,0.00005117389,0.00001360391,0.00006331057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004594933,"threshold_uncertainty_score":0.5933504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004647861526148139,"score_gpt":0.2081085793264739,"score_spread":0.2034607178003258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}