{"id":"W2138264320","doi":"10.1101/gad.191973.112","title":"The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis","year":2012,"lang":"en","type":"article","venue":"Genes & Development","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; U.S. Department of Defense; Stand Up To Cancer; Entertainment Industry Foundation; V Foundation for Cancer Research","keywords":"Biology; P110α; Carcinogenesis; Gene isoform; PI3K/AKT/mTOR pathway; Cancer research; Phosphoinositide 3-kinase; Receptor; Signal transduction; Cell biology; Cancer; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001245194,0.0003241947,0.000159208,0.000292704,0.000174722,0.0005751435,0.0001764086,0.0001861874,0.0004879368],"category_scores_gemma":[0.00009062255,0.000131694,0.000179066,0.0002331628,0.0002732398,0.0002318278,0.0002252857,0.0005730658,0.0002387681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004820029,"about_ca_system_score_gemma":0.0003461274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005736243,"about_ca_topic_score_gemma":0.000720642,"domain_scores_codex":[0.9998964,0.000008325204,0.000009117899,0.00002499812,0.00003181303,0.00002939804],"domain_scores_gemma":[0.9999458,0.000003781785,0.00001652433,0.000005580989,0.000005069166,0.00002318662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002077145,0.00002902677,0.001391822,0.00002705654,0.000006360714,0.00009042177,0.00001427331,0.00009804105,0.9898139,0.0007069452,0.00005341803,0.007561178],"study_design_scores_gemma":[0.00005853992,0.0003651843,0.04258056,0.00001149529,0.00004579007,0.001711929,0.00008108581,0.001582587,0.9439576,0.0009136559,0.008679962,0.00001164012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869373,0.004217418,0.004625618,0.0002289644,0.00002140113,0.00002271638,0.0002231897,0.00009317135,0.003630119],"genre_scores_gemma":[0.9937443,0.002799934,0.001222378,0.00005354527,0.000008430832,0.00001342557,0.0002349631,0.000009146034,0.001913878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005751435,"threshold_uncertainty_score":0.003497243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008824373487719287,"score_gpt":0.224709109908786,"score_spread":0.2158847364210667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}