{"id":"W2138266213","doi":"10.1210/en.2014-1519","title":"The Antidiabetic Hormone Glucagon-Like Peptide-1 Induces Formation of New Elastic Fibers in Human Cardiac Fibroblasts After Cross-Activation of IGF-IR","year":2014,"lang":"en","type":"article","venue":"Endocrinology","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Heart and Stroke Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Novo Nordisk; Heart and Stroke Foundation of Canada","keywords":"Endocrinology; Internal medicine; Elastin; Glucagon-like peptide-1; Receptor; Extracellular matrix; Stimulation; Glucagon-like peptide 1 receptor; Myocardial infarction; Chemistry; Medicine; Cell biology; Diabetes mellitus; Biology; Type 2 diabetes; Agonist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002448836,0.0003179698,0.000207132,0.0002485704,0.0001243436,0.000248915,0.00008836432,0.000249838,0.001368267],"category_scores_gemma":[0.000140545,0.0001784056,0.0004709476,0.000124989,0.0001290611,0.0001390943,0.0002082904,0.0005377441,0.0004869899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000112027,"about_ca_system_score_gemma":0.00009933396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003729608,"about_ca_topic_score_gemma":0.0004622509,"domain_scores_codex":[0.9998252,0.00004089897,0.00002332981,0.00003719063,0.00003387702,0.00003956118],"domain_scores_gemma":[0.9998515,0.00004473608,0.00003341722,0.00002189384,0.00001666353,0.00003176368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001984422,0.000060527,0.0002773438,0.00003270821,0.000006102106,0.0001973538,0.00003503963,0.00002342393,0.9979407,0.00003525038,0.00006086893,0.001132142],"study_design_scores_gemma":[0.00006889912,0.001473657,0.01869448,0.00001604367,0.00002633235,0.0007881395,0.0001196063,0.0007160949,0.9745085,0.00006303093,0.003514229,0.00001095976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926071,0.002155454,0.001854848,0.0001439578,0.0001168836,0.0000681996,0.0004213547,0.00004405889,0.00258817],"genre_scores_gemma":[0.9931305,0.00107879,0.001800212,0.0002276101,0.00003638834,0.00008029938,0.0006922368,0.00001117109,0.002942844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001368267,"threshold_uncertainty_score":0.004577279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01240893575298588,"score_gpt":0.2900065740284065,"score_spread":0.2775976382754206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}