{"id":"W2138266213","doi":"10.1210/en.2014-1519","title":"The Antidiabetic Hormone Glucagon-Like Peptide-1 Induces Formation of New Elastic Fibers in Human Cardiac Fibroblasts After Cross-Activation of IGF-IR","year":2014,"lang":"en","type":"article","venue":"Endocrinology","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Heart and Stroke Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Novo Nordisk; Heart and Stroke Foundation of Canada","keywords":"Endocrinology; Internal medicine; Elastin; Glucagon-like peptide-1; Receptor; Extracellular matrix; Stimulation; Glucagon-like peptide 1 receptor; Myocardial infarction; Chemistry; Medicine; Cell biology; Diabetes mellitus; Biology; Type 2 diabetes; Agonist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001391347,0.000118158,0.0001941267,0.0001042597,0.00005802399,0.000008782704,0.0001870258,0.0000946893,0.00001038377],"category_scores_gemma":[0.0002568368,0.0001039635,0.00007035973,0.000129374,0.0002274141,0.00001293164,0.0001369479,0.0001188254,0.000004780968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002154027,"about_ca_system_score_gemma":0.00005710831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002240191,"about_ca_topic_score_gemma":0.000133361,"domain_scores_codex":[0.9988819,0.0001585487,0.000297354,0.000218394,0.0001259809,0.0003177893],"domain_scores_gemma":[0.9993154,0.00009853009,0.0001318998,0.0003069809,0.0001118711,0.00003529533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002107166,0.00003758649,0.01156935,0.00003862175,0.00003824913,5.329616e-7,0.0002781022,0.0001864376,0.9823161,0.00014596,0.0003894828,0.0047888],"study_design_scores_gemma":[0.0006988235,0.0005487554,0.2769388,0.00001750999,0.000006530514,0.000001954779,0.0001239534,0.00003788806,0.7178665,0.0003658919,0.003291374,0.0001020051],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980165,0.0006965434,0.0004284883,0.0001102018,0.00008425027,0.0002234149,0.000005346565,0.00000513333,0.0004301422],"genre_scores_gemma":[0.9993676,0.0001339289,0.00005037028,0.00001497655,0.00006208666,0.00003737584,0.00003977259,0.00001387221,0.0002800273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2653694,"threshold_uncertainty_score":0.4239507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01240893575298588,"score_gpt":0.2900065740284065,"score_spread":0.2775976382754206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}