{"id":"W2138277779","doi":"10.1158/0008-5472.can-05-1186","title":"Efficient Deletion of Normal <i>Brca2</i>-Deficient Intestinal Epithelium by Poly(ADP-Ribose) Polymerase Inhibition Models Potential Prophylactic Therapy","year":2005,"lang":"en","type":"article","venue":"Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Toronto","keywords":"Poly ADP ribose polymerase; Intestinal epithelium; Polymerase; Epithelium; Cancer research; Molecular biology; Biology; Ribose; Medicine; Pathology; Biochemistry; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009580074,0.0002875244,0.0002323603,0.0001992931,0.0001061688,0.0002566866,0.0002359009,0.0003096298,0.001164712],"category_scores_gemma":[0.00006694991,0.0001257105,0.0002538718,0.00009774719,0.000194677,0.0001685158,0.0001535297,0.0007050433,0.0003743691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002158043,"about_ca_system_score_gemma":0.0001332934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002153798,"about_ca_topic_score_gemma":0.0003183071,"domain_scores_codex":[0.9999225,0.00001408038,0.00000578494,0.00001969899,0.00001880598,0.00001902969],"domain_scores_gemma":[0.999941,0.000008342234,0.00001898828,0.000009752966,0.000003698372,0.00001824243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002049119,0.00007116058,0.00009188249,0.00003597981,0.000004160408,0.00007108455,0.000008670844,0.0001050051,0.9969102,0.0001434434,0.00008830171,0.002265341],"study_design_scores_gemma":[0.00002969803,0.001208975,0.001596868,0.000008783812,0.00001850828,0.0006032152,0.00001839801,0.0007685127,0.9903396,0.00006336279,0.005339778,0.000004236125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759722,0.004480594,0.01343798,0.0003210559,0.0001332353,0.0001770889,0.0006572158,0.0004654628,0.0043551],"genre_scores_gemma":[0.9893522,0.002055841,0.003880948,0.00007871149,0.00001647953,0.00007742869,0.0004111164,0.00003418792,0.004093086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001164712,"threshold_uncertainty_score":0.003896296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05584133082506588,"score_gpt":0.3705531389634022,"score_spread":0.3147118081383363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}