{"id":"W2138282259","doi":"10.1016/s1474-4422(13)70258-8","title":"Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study","year":2013,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":438,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Children's Hospital","funders":"National Center for Research Resources","keywords":"ADAR; SAMHD1; Interferon; Genetics; Virology; Biology; Medicine; Polymerase chain reaction; Gene; RNA; Reverse transcriptase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009907368,0.001205806,0.0009493392,0.002000578,0.001049493,0.0008440928,0.0007043956,0.001637714,0.00157492],"category_scores_gemma":[0.002815922,0.0007130196,0.0007742395,0.0009685069,0.001043506,0.0005765004,0.000450771,0.0006751199,0.0001933779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005974003,"about_ca_system_score_gemma":0.0002879614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002736549,"about_ca_topic_score_gemma":0.001698374,"domain_scores_codex":[0.9991155,0.0002359525,0.0001251317,0.0002868937,0.0001431826,0.00009325977],"domain_scores_gemma":[0.9985684,0.0006012416,0.0003727993,0.0001217463,0.000144734,0.0001909593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001769274,0.0004364986,0.9678187,0.00005311468,0.0003191394,0.01877812,0.0006470743,0.0001329573,0.006478501,0.0001433024,0.0001408111,0.003282604],"study_design_scores_gemma":[0.0002260412,0.001099822,0.954909,0.00003327577,0.0003689235,0.04043316,0.0004680595,0.0009945477,0.000935763,0.000161788,0.0003317734,0.00003775713],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993786,0.0002242819,0.0001351739,0.00001613236,0.000004685982,0.00001383243,0.00004534048,0.000003838,0.0001782827],"genre_scores_gemma":[0.9996065,0.00008581005,0.0001347531,0.00002035293,0.00001191487,0.000008899755,0.00005102774,0.000002340603,0.00007841796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002736549,"threshold_uncertainty_score":0.005441308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01235999424511669,"score_gpt":0.2552329367692237,"score_spread":0.242872942524107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}