{"id":"W2138319875","doi":"10.1128/mcb.00349-14","title":"Chromatin Profiling Reveals Regulatory Network Shifts and a Protective Role for Hepatocyte Nuclear Factor 4α during Colitis","year":2014,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; Princess Margaret Cancer Centre; University Health Network","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Canadian Institutes of Health Research; Toyota Research Institute, North America","keywords":"Hepatocyte nuclear factors; Transcription factor; Biology; Chromatin; Inflammatory bowel disease; Enhancer; Epigenetics; Inflammation; Epigenomics; FOXA1; Colitis; Genetics; Regulation of gene expression; Immunology; Cell biology; Cancer research; Gene expression; Gene; Disease; Medicine; Pathology; DNA methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008944976,0.0001010661,0.00013875,0.0003174921,0.0001144681,0.0001746888,0.00009413243,0.0001427734,0.001277589],"category_scores_gemma":[0.0001096884,0.000126247,0.0001541281,0.0002219281,0.0001665131,0.0001151161,0.0001205904,0.0002073773,0.0002211704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001852385,"about_ca_system_score_gemma":0.00009758968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008233234,"about_ca_topic_score_gemma":0.001498344,"domain_scores_codex":[0.9999129,0.00001064971,0.000004152574,0.00002895152,0.00001564902,0.00002779473],"domain_scores_gemma":[0.9999281,0.000009282541,0.00002311563,0.00001013476,0.000009812905,0.00001958631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001484359,0.00000558327,0.001307323,0.00001025035,0.000003895164,0.00001892689,0.0000146318,0.000031219,0.9972854,0.00002390822,0.00001602315,0.001134368],"study_design_scores_gemma":[0.00002042767,0.0003503973,0.3307174,0.000009793511,0.00003758399,0.0005650255,0.0002097847,0.001734832,0.663753,0.0002712569,0.002316659,0.00001380356],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942404,0.001021078,0.003239805,0.00005386663,0.00001159682,0.00001015478,0.0006679661,0.00007318717,0.0006818279],"genre_scores_gemma":[0.9963157,0.0004140781,0.001066544,0.00003529724,0.000004867752,0.00001515059,0.0005909759,0.00001342043,0.001544034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001277589,"threshold_uncertainty_score":0.004274011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005594632407861611,"score_gpt":0.2023443150277767,"score_spread":0.1967496826199151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}