{"id":"W2138331996","doi":"10.1038/ejhg.2011.131","title":"iPS cells to model CDKL5-related disorders","year":2011,"lang":"en","type":"article","venue":"European Journal of Human Genetics","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; SickKids Foundation","funders":"Canadian Institutes of Health Research","keywords":"Rett syndrome; Induced pluripotent stem cell; Biology; MECP2; Mutation; Genetics; Gene; Phenotype; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005108188,0.0005155819,0.0003712568,0.0009100751,0.0004309753,0.0007670266,0.0007317961,0.001064463,0.004470544],"category_scores_gemma":[0.0003613547,0.000286064,0.0005295461,0.0003267742,0.0005983245,0.00042128,0.0005484795,0.001983298,0.001685325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000616259,"about_ca_system_score_gemma":0.0003338967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006094432,"about_ca_topic_score_gemma":0.0006735569,"domain_scores_codex":[0.9996592,0.00005284628,0.00005732702,0.00005847755,0.0001240132,0.00004813972],"domain_scores_gemma":[0.9997616,0.00007348706,0.00004954098,0.00005082888,0.00002230282,0.00004214951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003417241,0.0001991188,0.0005283779,0.0002248542,0.00005950009,0.001740046,0.0001793357,0.002801556,0.9696636,0.01403218,0.001507857,0.008721875],"study_design_scores_gemma":[0.00009647819,0.0001484566,0.0007517767,0.00003361969,0.00008611091,0.001624396,0.00006872782,0.005233317,0.9569683,0.001098089,0.03387699,0.00001370509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8630031,0.004273531,0.07144419,0.001434615,0.001387178,0.0008501704,0.01111335,0.001260239,0.04523369],"genre_scores_gemma":[0.9607484,0.001631137,0.01585003,0.0002772286,0.00005144168,0.0003755706,0.003265064,0.0002182604,0.01758295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004470544,"threshold_uncertainty_score":0.01495552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02004177158073284,"score_gpt":0.2201511509724945,"score_spread":0.2001093793917617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}