{"id":"W2138336030","doi":"10.1186/s13059-015-0583-7","title":"Chromosome 7 gain and DNA hypermethylation at the HOXA10 locus are associated with expression of a stem cell related HOX-signature in glioblastoma","year":2015,"lang":"en","type":"article","venue":"Genome Biology","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"National Human Genome Research Institute; Ludwig Center at Harvard; Universitätsspital Zürich; Université de Lausanne; National Cancer Institute; Weizmann Institute of Science; University of Toronto; Universiteit Gent; Eberhard Karls Universität Tübingen; Curtin University of Technology; Australian National University; Centre Hospitalier Universitaire Vaudois; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Ben-Gurion University of the Negev; National Science Foundation","keywords":"Biology; Hox gene; DNA methylation; Genetics; Glioblastoma; Human genetics; Chromosome; Gene; Cancer research; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007494693,0.0002004254,0.0001680367,0.0005887067,0.0001038089,0.0001368213,0.000110106,0.0001764072,0.00165306],"category_scores_gemma":[0.0001975866,0.00009805564,0.0001101096,0.0002277532,0.0002243265,0.00007260978,0.0001819515,0.0001804117,0.0002004652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001764612,"about_ca_system_score_gemma":0.0001881991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006330932,"about_ca_topic_score_gemma":0.001039591,"domain_scores_codex":[0.9999264,0.000007178866,0.000006651312,0.00001745101,0.00002542688,0.0000168629],"domain_scores_gemma":[0.9997775,0.00002422026,0.0001135846,0.0000108722,0.0000168537,0.00005705694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000704304,0.00004474444,0.09802627,0.00006304077,0.00005421265,0.001914612,0.00007748448,0.0001063501,0.8928819,0.0001391434,0.0001385787,0.005849272],"study_design_scores_gemma":[0.00002254638,0.0003084722,0.8814067,0.00001043783,0.00009362636,0.01077476,0.000101838,0.0005136766,0.1056277,0.0003401641,0.0007914652,0.000008472568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990073,0.0002848168,0.0003057399,0.00001943561,0.000002829085,0.000005076392,0.00007677745,0.00001897722,0.0002790042],"genre_scores_gemma":[0.9990547,0.0001781998,0.0002793031,0.00001154297,0.000004448064,0.00000691909,0.0001844324,0.000004777148,0.0002756598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00165306,"threshold_uncertainty_score":0.00553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006945973945565679,"score_gpt":0.2019244983868594,"score_spread":0.1949785244412937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}