{"id":"W2138342695","doi":"10.1002/eji.200324400","title":"The RhoA‐ and CDC42‐specific exchange factor Dbs promotes expansion of immature thymocytes and deletion of double‐positive and single‐positive thymocytes","year":2004,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Thymocyte; Double negative; Biology; Transgene; RHOA; T-cell receptor; Guanine nucleotide exchange factor; In vivo; Cell biology; RAC1; Genetically modified mouse; Molecular biology; CDC42; T cell; GTPase; Immunology; Signal transduction; Genetics; Immune system; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007633222,0.0003690038,0.0002306562,0.0002689622,0.00008306394,0.0002246698,0.0001599944,0.0001288967,0.000929223],"category_scores_gemma":[0.00008263486,0.000136938,0.0001318499,0.00009937195,0.0001584509,0.000101021,0.0002350735,0.0005901583,0.000286428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001372551,"about_ca_system_score_gemma":0.0001202744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001579507,"about_ca_topic_score_gemma":0.000445864,"domain_scores_codex":[0.9998454,0.0000167545,0.000009201659,0.00002447447,0.00006097463,0.00004311355],"domain_scores_gemma":[0.9998525,0.0000211669,0.00003158983,0.0000141697,0.00000894348,0.0000715201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002441427,0.00001081724,0.00005013774,0.000007149511,8.027828e-7,0.000026276,0.000003860556,0.00001471009,0.999395,0.00002817662,0.000009676406,0.0004290321],"study_design_scores_gemma":[0.00001136226,0.0001937725,0.003444275,0.000003451658,0.000007465963,0.0003598956,0.00001173522,0.0004351895,0.994238,0.00003418142,0.001258262,0.000002455527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971252,0.0005104168,0.001045349,0.00002343405,0.00001102307,0.000009795856,0.00008233679,0.00006884267,0.001123525],"genre_scores_gemma":[0.9947115,0.000488313,0.001235324,0.00001799803,0.00001125537,0.00001514813,0.0002824355,0.00002606571,0.003211914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000929223,"threshold_uncertainty_score":0.003108621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01070511834477842,"score_gpt":0.2121536928241686,"score_spread":0.2014485744793902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}