{"id":"W2138359733","doi":"10.1124/dmd.105.005074","title":"PULMONARY BIOACTIVATION OF TRICHLOROETHYLENE TO CHLORAL HYDRATE: RELATIVE CONTRIBUTIONS OF CYP2E1, CYP2F, AND CYP2B1","year":2005,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"National Institute of Environmental Health Sciences; National Heart, Lung, and Blood Institute","keywords":"Microsome; CYP2E1; Recombinant DNA; Chloral hydrate; Cytochrome P450; Chemistry; Hydroxylation; Microsoma; Biochemistry; Cytochrome; Unspecific monooxygenase; Metabolism; Enzyme; Molecular biology; Biology; Pharmacology; CYP1A2; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007132829,0.0002494849,0.0004869041,0.0003047361,0.0002048349,0.00001418947,0.00011846,0.0001975983,0.0000958776],"category_scores_gemma":[0.0000869808,0.0002378431,0.00009062883,0.0004377008,0.0002438309,0.000396836,0.0001007526,0.0003048379,0.00001035489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002302629,"about_ca_system_score_gemma":0.00004731161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005994872,"about_ca_topic_score_gemma":0.000005111453,"domain_scores_codex":[0.9982315,0.0003363009,0.0005716382,0.0003460396,0.0001988839,0.000315589],"domain_scores_gemma":[0.99875,0.0002349724,0.0002870856,0.0001570201,0.0002613189,0.0003095479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009640194,0.0005577655,0.001254553,0.00007004907,0.0001731604,0.000004152932,0.002116707,0.0004701889,0.894807,0.02375732,0.0002523951,0.07557267],"study_design_scores_gemma":[0.002665764,0.00006064492,0.04664217,0.00003149293,0.0006919857,0.00002311241,0.0002286764,0.00359659,0.9079194,0.002677958,0.03512035,0.0003418812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829484,0.01027061,0.001197093,0.001930341,0.0003915329,0.0005601544,0.0007932901,0.00003235355,0.00187622],"genre_scores_gemma":[0.9953762,0.002627873,0.0006635624,0.0006206282,0.0003175897,0.00005150339,0.0001300654,0.00001936137,0.0001932671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07523079,"threshold_uncertainty_score":0.9698959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02971548909317086,"score_gpt":0.3724688113440229,"score_spread":0.342753322250852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}