{"id":"W2138359733","doi":"10.1124/dmd.105.005074","title":"PULMONARY BIOACTIVATION OF TRICHLOROETHYLENE TO CHLORAL HYDRATE: RELATIVE CONTRIBUTIONS OF CYP2E1, CYP2F, AND CYP2B1","year":2005,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"National Institute of Environmental Health Sciences; National Heart, Lung, and Blood Institute","keywords":"Microsome; CYP2E1; Recombinant DNA; Chloral hydrate; Cytochrome P450; Chemistry; Hydroxylation; Microsoma; Biochemistry; Cytochrome; Unspecific monooxygenase; Metabolism; Enzyme; Molecular biology; Biology; Pharmacology; CYP1A2; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005240393,0.0002807016,0.0002806628,0.0002902582,0.0002424581,0.0004207001,0.000271957,0.0003652039,0.001162875],"category_scores_gemma":[0.0007561748,0.0001968163,0.0003849264,0.0002579995,0.0004275165,0.0002354384,0.0002149972,0.0004087215,0.0002353328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006023134,"about_ca_system_score_gemma":0.0005935353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008084039,"about_ca_topic_score_gemma":0.007605848,"domain_scores_codex":[0.9996532,0.000155035,0.0000129981,0.00004326993,0.00007805512,0.00005744084],"domain_scores_gemma":[0.9995971,0.0001523477,0.00007655993,0.0000557579,0.00006210914,0.0000561643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004678717,0.00007048427,0.01720716,0.0001214686,0.0001458312,0.0006500499,0.0001866532,0.0007571582,0.9566592,0.000344164,0.0002845255,0.01889453],"study_design_scores_gemma":[0.00004546999,0.00119796,0.08420462,0.00001083756,0.0001174306,0.002502828,0.0002144024,0.003662579,0.9059415,0.00009665452,0.00198543,0.00002030697],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922876,0.002813675,0.003231132,0.000159622,0.00001361905,0.00003572252,0.00008569664,0.0000335808,0.001339314],"genre_scores_gemma":[0.9978899,0.0006666377,0.0005364464,0.00003099867,0.000009120385,0.00001144304,0.00009314812,0.000008377639,0.0007538357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008084039,"threshold_uncertainty_score":0.01607394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02971548909317086,"score_gpt":0.3724688113440229,"score_spread":0.342753322250852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}