{"id":"W2138363022","doi":"10.1534/genetics.112.143743","title":"Targeting of &amp;gt;1.5 Mb of Human DNA into the Mouse X Chromosome Reveals Presence of <i>cis</i>-Acting Regulators of Epigenetic Silencing","year":2012,"lang":"en","type":"article","venue":"Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"DNA methylation; Biology; X-inactivation; Epigenetics; Genetics; Gene; Epigenetics of physical exercise; DNA; Molecular biology; CpG site; Methylation; X chromosome; Promoter; RNA-Directed DNA Methylation; Locus (genetics); Chromosome; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009156296,0.0001982564,0.0003708496,0.00007320604,0.00008137166,0.000005092719,0.0003829496,0.0001894366,0.00002109672],"category_scores_gemma":[0.0003308824,0.0001739599,0.0001503008,0.0002074905,0.0002854796,0.000006566137,0.0002464461,0.00009153298,6.448782e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001186267,"about_ca_system_score_gemma":0.00005861721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000595844,"about_ca_topic_score_gemma":0.00002424828,"domain_scores_codex":[0.9979566,0.0001867508,0.0009330015,0.0002489279,0.0003456291,0.00032911],"domain_scores_gemma":[0.9978097,0.00008361493,0.0009479503,0.0007395823,0.0003327819,0.00008633926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001675197,0.00007828821,0.01660187,0.0001927541,0.00005239795,5.299345e-8,0.001661091,0.002111988,0.9780371,0.00005643854,0.00003021656,0.001161001],"study_design_scores_gemma":[0.0001957886,0.0002626384,0.003951421,0.00005607842,0.00005601512,5.320641e-7,0.0004150038,0.00004776653,0.9942253,0.0001826685,0.000447133,0.0001596291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864083,0.01014203,0.002839681,0.00001043034,0.00009419935,0.0002619642,0.00002252594,0.000004320558,0.0002165506],"genre_scores_gemma":[0.9931621,0.0007606167,0.005735265,0.00000746922,0.0001594469,0.000007428314,0.00005298015,0.00003724968,0.00007745165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01618818,"threshold_uncertainty_score":0.7093878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01914945548412483,"score_gpt":0.2801392127517898,"score_spread":0.260989757267665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}