{"id":"W2138363022","doi":"10.1534/genetics.112.143743","title":"Targeting of &amp;gt;1.5 Mb of Human DNA into the Mouse X Chromosome Reveals Presence of <i>cis</i>-Acting Regulators of Epigenetic Silencing","year":2012,"lang":"en","type":"article","venue":"Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"DNA methylation; Biology; X-inactivation; Epigenetics; Genetics; Gene; Epigenetics of physical exercise; DNA; Molecular biology; CpG site; Methylation; X chromosome; Promoter; RNA-Directed DNA Methylation; Locus (genetics); Chromosome; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001691286,0.0003004433,0.0002737681,0.0002920943,0.0001276306,0.0003630543,0.0001986684,0.0003272815,0.002244034],"category_scores_gemma":[0.0001156967,0.0002540374,0.0002711585,0.0002029961,0.0003237203,0.0001592234,0.0002831676,0.0005845657,0.0007304181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000271318,"about_ca_system_score_gemma":0.0002307953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008360171,"about_ca_topic_score_gemma":0.001461715,"domain_scores_codex":[0.9998276,0.00002031637,0.00001208534,0.00007252219,0.00003258899,0.00003489862],"domain_scores_gemma":[0.9999058,0.00002408171,0.0000331838,0.00001223013,0.000005086499,0.00001960198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003976289,0.000009215091,0.0002087123,0.00002565058,0.000005145844,0.00002650169,0.00001563309,0.00004119411,0.997641,0.00007831072,0.00002550233,0.001883483],"study_design_scores_gemma":[0.00001049254,0.0002190269,0.008031694,0.00001036728,0.00002215507,0.0001808279,0.00002380535,0.0004462563,0.9872797,0.00005571255,0.003716697,0.000003381282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9785001,0.003214042,0.01432017,0.0001996597,0.000034843,0.00006153174,0.001064329,0.0002652892,0.002340096],"genre_scores_gemma":[0.9786882,0.001411119,0.01085272,0.0000916972,0.00001579763,0.00007925294,0.002478787,0.00009689922,0.006285525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002244034,"threshold_uncertainty_score":0.007507026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01914945548412483,"score_gpt":0.2801392127517898,"score_spread":0.260989757267665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}