{"id":"W2138364237","doi":"10.1083/jcb.200604009","title":"Promyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR","year":2006,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":177,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Princess Margaret Cancer Centre; Hospital for Sick Children; Dalhousie University","funders":"","keywords":"Biology; DNA damage; DNA repair; Cell biology; Promyelocytic leukemia protein; Chromatin; DNA replication; DNA; Cell cycle; Molecular biology; Nuclear protein; Transcription factor; Genetics; Cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001317732,0.0002924122,0.000239064,0.0002537443,0.0002359234,0.0004095497,0.0001732214,0.0003055496,0.0008352483],"category_scores_gemma":[0.0001545911,0.0002006369,0.0001684702,0.000170111,0.0003399171,0.0003855871,0.0002468167,0.000292111,0.0007038937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003372504,"about_ca_system_score_gemma":0.0001226983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00014944,"about_ca_topic_score_gemma":0.0002507429,"domain_scores_codex":[0.9998951,0.00001934244,0.000005930871,0.00002620322,0.00003546161,0.00001784103],"domain_scores_gemma":[0.9998887,0.00001368545,0.00003653143,0.0000209706,0.00001412957,0.00002603966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001434647,0.000009198188,0.0004436943,0.00002074369,0.000002682816,0.00003935405,0.00002100947,0.00007050092,0.9970445,0.0004454888,0.00004279087,0.00171654],"study_design_scores_gemma":[0.00001858352,0.00006835168,0.003526304,0.000003979653,0.000007953725,0.0002741386,0.00003030011,0.0006401478,0.9918819,0.0004141179,0.003129989,0.00000428261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819965,0.004051641,0.008913985,0.0001977873,0.00005314612,0.00003798815,0.0003215144,0.0002900019,0.004137523],"genre_scores_gemma":[0.9916406,0.001051542,0.004156196,0.00004079733,0.00001078034,0.00001804104,0.0002402592,0.00002285033,0.002818997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008352483,"threshold_uncertainty_score":0.002794147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003843613194988082,"score_gpt":0.215907100610427,"score_spread":0.212063487415439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}