{"id":"W2138366034","doi":"10.1517/14656566.9.2.311","title":"Idursulfase for the treatment of mucopolysaccharidosis II","year":2008,"lang":"en","type":"review","venue":"Expert Opinion on Pharmacotherapy","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute","funders":"","keywords":"Hunter syndrome; Enzyme replacement therapy; Recombinant DNA; Medicine; Mucopolysaccharidosis; Mucopolysaccharidosis type II; Disease; Glycosylation; Genetic enhancement; Bioinformatics; Internal medicine; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001002873,0.0006011206,0.001755723,0.0003014126,0.0003338616,0.0000129489,0.0003720039,0.0002383132,0.0008658657],"category_scores_gemma":[0.0000258224,0.0003253202,0.001572404,0.0003898792,0.0001723026,0.00003754224,0.00002181175,0.0002146643,0.00003905861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004062407,"about_ca_system_score_gemma":0.0004649185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008406505,"about_ca_topic_score_gemma":5.028182e-7,"domain_scores_codex":[0.9976229,0.0001340831,0.0006543171,0.0005569252,0.0005889992,0.0004427461],"domain_scores_gemma":[0.9980279,0.0006215834,0.0003027122,0.00072315,0.0001311829,0.0001934394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005757606,0.002001374,7.275727e-7,0.0008484807,0.001200323,0.000007912803,0.0008549267,3.293967e-7,0.00008927273,0.00003451373,0.03440644,0.95998],"study_design_scores_gemma":[0.004461422,0.003556667,3.797899e-7,0.001647292,0.00008010279,0.00005483724,0.00003393205,0.00004122488,0.001501031,0.000002431218,0.9883547,0.0002659922],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000009591028,0.9921864,0.00006931011,0.0009314875,0.00107836,0.005332489,0.0001525135,0.00006436019,0.0001755073],"genre_scores_gemma":[0.000003876211,0.9930264,0.0001485619,0.0006123773,0.001384446,0.003144021,0.000169213,0.0001686567,0.001342419],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9597139,"threshold_uncertainty_score":0.9999199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1778189460266111,"score_gpt":0.4863654061848031,"score_spread":0.308546460158192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}