{"id":"W2138388777","doi":"10.1136/thoraxjnl-2012-202678.126","title":"S121 Lung Clearance Index to Evaluate the Effect of Ivacaftor on Lung Function in Subjects with CF Who Have the G551D-CFTR Mutation and Mild Lung Disease","year":2012,"lang":"en","type":"article","venue":"Thorax","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Medical Research Council; National Institute for Health and Care Research","keywords":"Ivacaftor; Medicine; Exacerbation; Crossover study; Placebo; Pulmonary function testing; Internal medicine; Washout; Lung function; Lung; Cystic fibrosis; Gastroenterology; Pathology; Cystic fibrosis transmembrane conductance regulator","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001142399,0.0009113055,0.002054879,0.0004346661,0.0002512321,0.0003875465,0.0004533494,0.001181529,0.003487916],"category_scores_gemma":[0.001079485,0.0002663349,0.001476981,0.0003795614,0.0003109497,0.0003542143,0.000250896,0.001112564,0.000634046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004302957,"about_ca_system_score_gemma":0.0005591942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001101051,"about_ca_topic_score_gemma":0.001343606,"domain_scores_codex":[0.9993902,0.0002241643,0.00006740205,0.0001048817,0.000151184,0.0000621019],"domain_scores_gemma":[0.9985737,0.0002704998,0.0004056278,0.00008159981,0.0001384036,0.0005301505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.667853,0.01976076,0.134198,0.00147053,0.00167991,0.0002172428,0.0001356381,0.001227348,0.0837569,0.0001081374,0.002712163,0.08688036],"study_design_scores_gemma":[0.05482226,0.4297284,0.4880831,0.0000722666,0.0009631643,0.0004448284,0.00005580913,0.002344108,0.02085776,0.00006488311,0.002497546,0.00006587854],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892628,0.003475216,0.0004584969,0.0001126732,0.0001079519,0.001862249,0.001908369,0.0001370766,0.002675202],"genre_scores_gemma":[0.9950249,0.0004250156,0.0007752324,0.0002371542,0.00008265471,0.0006824736,0.001463387,0.00001244343,0.001296768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003487916,"threshold_uncertainty_score":0.01166826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01184565108535458,"score_gpt":0.3307522191846567,"score_spread":0.3189065680993022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}