{"id":"W2138397090","doi":"10.1038/ncomms4650","title":"Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":150,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canada Excellence Research Chairs, Government of Canada; National Human Genome Research Institute; Dana-Farber Cancer Institute; National Institute of Mental Health; Fonds De La Recherche Scientifique - FNRS; Vlaamse regering; Fonds Wetenschappelijk Onderzoek; Simons Foundation Autism Research Initiative; Simons Foundation; National Institutes of Health; National Science Foundation","keywords":"Interactome; Autism; Gene isoform; RNA splicing; Computational biology; Alternative splicing; Autism spectrum disorder; Biology; Genetic variants; Protein–protein interaction; Genetics; Neuroscience; Bioinformatics; Gene; Medicine; RNA; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002252954,0.0001347895,0.0001543053,0.00002305496,0.0001819135,0.00002154141,0.0006713809,0.0005309022,0.000005155156],"category_scores_gemma":[0.0002225159,0.0001187457,0.0001174362,0.00007189222,0.00007631483,0.000006688142,0.0002455433,0.0005932483,0.000002407868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001644817,"about_ca_system_score_gemma":0.00003214382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000992357,"about_ca_topic_score_gemma":0.0004417659,"domain_scores_codex":[0.9991918,0.00008863281,0.0003228798,0.0001607856,0.00006966551,0.0001662813],"domain_scores_gemma":[0.9982203,0.0001878554,0.0003707152,0.001066242,0.0001045333,0.00005032868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008636277,0.001056661,0.04448944,0.0001975909,0.002375602,2.405911e-7,0.003678453,0.01395607,0.5330817,0.06359105,0.07538518,0.2613243],"study_design_scores_gemma":[0.002124411,0.0008051615,0.0894292,0.0001617304,0.0001639766,0.000002562272,0.0002593794,0.1018649,0.03381443,0.02715698,0.743409,0.0008083048],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8709992,0.00179534,0.1234595,0.0012901,0.0003190363,0.0008240438,0.0002564978,0.00002167314,0.001034567],"genre_scores_gemma":[0.9565141,0.0002326866,0.04167296,0.0002769192,0.0001864834,0.00006325405,0.0009133954,0.00001904749,0.0001212054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6680238,"threshold_uncertainty_score":0.4842309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01126771036639023,"score_gpt":0.2736692507526712,"score_spread":0.2624015403862809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}