{"id":"W2138397090","doi":"10.1038/ncomms4650","title":"Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":150,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canada Excellence Research Chairs, Government of Canada; National Human Genome Research Institute; Dana-Farber Cancer Institute; National Institute of Mental Health; Fonds De La Recherche Scientifique - FNRS; Vlaamse regering; Fonds Wetenschappelijk Onderzoek; Simons Foundation Autism Research Initiative; Simons Foundation; National Institutes of Health; National Science Foundation","keywords":"Interactome; Autism; Gene isoform; RNA splicing; Computational biology; Alternative splicing; Autism spectrum disorder; Biology; Genetic variants; Protein–protein interaction; Genetics; Neuroscience; Bioinformatics; Gene; Medicine; RNA; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001818259,0.000342537,0.0002926658,0.001948831,0.0005365824,0.0004948791,0.0002512685,0.0002802251,0.001917643],"category_scores_gemma":[0.0007644341,0.0002006134,0.0005611035,0.001433782,0.0001857156,0.0003883905,0.0004427054,0.0002728852,0.0005409074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004375863,"about_ca_system_score_gemma":0.0003967938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002422838,"about_ca_topic_score_gemma":0.004393992,"domain_scores_codex":[0.9997398,0.00004147607,0.00001735916,0.0001048296,0.00006523384,0.00003130452],"domain_scores_gemma":[0.9996344,0.0001370619,0.0001115811,0.00003352049,0.00004397705,0.00003945763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001075001,0.0002429301,0.2632565,0.0005772499,0.0006970228,0.002472383,0.00040993,0.03740351,0.6213354,0.009325448,0.004268024,0.05893664],"study_design_scores_gemma":[0.00003592958,0.0001815904,0.6516421,0.00005839532,0.0005966627,0.003213932,0.0003088924,0.2409733,0.07222445,0.0169459,0.01376135,0.000057606],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.969744,0.000758459,0.02030852,0.0002260807,0.00001023552,0.00002333397,0.005823654,0.000348877,0.002756751],"genre_scores_gemma":[0.9621157,0.0008715168,0.01830524,0.0000633375,0.00001216241,0.00006602125,0.01700982,0.00005612794,0.001500048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002422838,"threshold_uncertainty_score":0.006415129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01126771036639023,"score_gpt":0.2736692507526712,"score_spread":0.2624015403862809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}