{"id":"W2138401012","doi":"10.1186/1743-422x-3-66","title":"Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression.","year":2006,"lang":"en","type":"article","venue":"Virology Journal","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Medical Research Council; Academy of Finland; European Commission","keywords":"Biology; NS3; Proteases; NS2-3 protease; Gene expression; Molecular biology; Virology; Hepatitis C virus; Virus; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027096,0.0005454443,0.0002458141,0.0001986227,0.000158043,0.0002377753,0.0001268266,0.0002062777,0.001985736],"category_scores_gemma":[0.0001358626,0.0001016187,0.0003369674,0.0001321416,0.0002070386,0.0001390232,0.0001520196,0.0003010044,0.0006088165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000304901,"about_ca_system_score_gemma":0.0002366301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003030927,"about_ca_topic_score_gemma":0.0006716817,"domain_scores_codex":[0.9997664,0.00005407864,0.00001776488,0.00002849491,0.00008141355,0.00005186887],"domain_scores_gemma":[0.9998541,0.0000335432,0.00004789123,0.00001411698,0.00002325554,0.00002706585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001186508,0.00003338033,0.0002718302,0.00007645629,0.00001096563,0.0000227567,0.000003940077,0.00006628064,0.9966544,0.00007634197,0.00006569577,0.002599293],"study_design_scores_gemma":[0.00001788004,0.000544303,0.003010533,0.000007862557,0.00001815517,0.0002714435,0.00000669386,0.0003549642,0.9900612,0.00003286332,0.0056706,0.000003672798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9577399,0.02874256,0.007025378,0.000164724,0.0001211093,0.0001327256,0.0007986411,0.0001638767,0.005111012],"genre_scores_gemma":[0.9823517,0.005491853,0.005686274,0.0001008884,0.00005143127,0.0001365448,0.001361806,0.00003282589,0.004786657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001985736,"threshold_uncertainty_score":0.006642938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004932649920208157,"score_gpt":0.1930390902929555,"score_spread":0.1881064403727474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}