{"id":"W2138414945","doi":"10.1128/aac.00591-12","title":"Antiviral Drug Resistance and the Need for Development of New HIV-1 Reverse Transcriptase Inhibitors","year":2012,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Reverse transcriptase; Nucleoside Reverse Transcriptase Inhibitor; Reverse-transcriptase inhibitor; Virology; Drug resistance; Drug; Biology; Human immunodeficiency virus (HIV); Medicine; Antiretroviral therapy; Pharmacology; Viral load; RNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002200137,0.0001773678,0.0003206667,0.00004853223,0.0001368315,0.0000149872,0.00004480603,0.00004769285,0.0000289],"category_scores_gemma":[0.000006055374,0.0001135128,0.00008090162,0.0000833056,0.0001281943,0.00008364601,0.00001361809,0.00005505021,0.00000335909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002031028,"about_ca_system_score_gemma":0.00007226483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009677401,"about_ca_topic_score_gemma":0.000007736896,"domain_scores_codex":[0.9991776,0.00001781807,0.0002831035,0.0001693722,0.0001057,0.0002463891],"domain_scores_gemma":[0.9996427,0.00002678078,0.00008628884,0.0001111995,0.00002927147,0.0001037325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004164633,0.0005988947,0.05996938,0.0003921333,0.0006759077,0.00000394558,0.04262292,4.370127e-8,0.01314976,0.0004304369,0.8547488,0.02324313],"study_design_scores_gemma":[0.0206487,0.00001853634,0.01215202,0.0002565387,0.0001749473,0.000008428158,0.0004338011,0.000005275451,0.1174756,0.00003780648,0.8485505,0.000237854],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975446,0.0003359493,0.0002699668,0.02271412,0.0001213178,0.0007867669,0.00001428481,0.00001751162,0.0002940368],"genre_scores_gemma":[0.9415318,0.0007670786,0.01588428,0.00346086,0.0001539589,0.00001647226,0.00005732824,0.00003120639,0.03809704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1043258,"threshold_uncertainty_score":0.4628917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01541794187393375,"score_gpt":0.2519633552548478,"score_spread":0.2365454133809141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}