{"id":"W2138447230","doi":"10.1016/s1474-4422(11)70024-2","title":"Emerging targets and treatments in amyotrophic lateral sclerosis","year":2011,"lang":"en","type":"review","venue":"The Lancet Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Amyotrophic lateral sclerosis; Riluzole; Motor neuron; Disease; Neuroscience; Medicine; Physical medicine and rehabilitation; Psychology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001402026,0.001451571,0.003418168,0.002753406,0.0003349485,0.00175609,0.00124806,0.002095933,0.004132734],"category_scores_gemma":[0.001640896,0.0004631768,0.0009525202,0.002845317,0.0007564087,0.002015024,0.000915182,0.003338758,0.002020056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001095111,"about_ca_system_score_gemma":0.001792477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002194792,"about_ca_topic_score_gemma":0.005245294,"domain_scores_codex":[0.9995822,0.00008159409,0.00007231359,0.00004956791,0.0001715047,0.00004277131],"domain_scores_gemma":[0.9992213,0.0004734697,0.000118257,0.00001571554,0.0001296162,0.00004160062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002663647,0.00008261256,0.000124325,0.03116472,0.0003016742,0.0002214868,0.00005380918,0.0004900342,0.0009613569,0.003579284,0.05803954,0.9047148],"study_design_scores_gemma":[0.0001835863,0.0001687309,0.0007439864,0.0122092,0.000652141,0.0007761271,0.00009610328,0.0001370384,0.0002293508,0.003790586,0.9809807,0.00003240538],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002046204,0.999318,0.00003063851,0.0001814656,0.0001679234,0.000002481143,0.000008945802,0.000002624839,0.0002675073],"genre_scores_gemma":[0.0002750067,0.998923,0.0001047545,0.0002682524,0.0001774424,0.000005155416,0.00001533473,7.163811e-7,0.0002303291],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004132734,"threshold_uncertainty_score":0.01382542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1599101619039666,"score_gpt":0.3659193167322228,"score_spread":0.2060091548282563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}