{"id":"W2138533693","doi":"10.1186/1742-2094-9-237","title":"SOD1 aggregation in astrocytes following ischemia/reperfusion injury: a role of NO-mediated S-nitrosylation of protein disulfide isomerase (PDI)","year":2012,"lang":"en","type":"article","venue":"Journal of Neuroinflammation","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China; Muscular Dystrophy Association","keywords":"Protein disulfide-isomerase; Chemistry; Superoxide dismutase; S-Nitrosylation; Reperfusion injury; Protein aggregation; Nitrosylation; SOD1; Ischemia; Astrocyte; Neurodegeneration; Biochemistry; Oxidative stress; Cell biology; Molecular biology; Biology; Nitric oxide; Cysteine; Pathology; Medicine; Enzyme; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002056177,0.0004385288,0.0003459979,0.0002465335,0.0002633983,0.0002775302,0.0001416076,0.0002620436,0.0004661184],"category_scores_gemma":[0.00009912409,0.000139105,0.0003097632,0.0002081477,0.000248095,0.0001875006,0.0001708368,0.000400953,0.000178034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002251665,"about_ca_system_score_gemma":0.0001710156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004645198,"about_ca_topic_score_gemma":0.0005520876,"domain_scores_codex":[0.9998811,0.00001521144,0.0000157282,0.00003059438,0.0000340002,0.00002330945],"domain_scores_gemma":[0.9998642,0.000008303282,0.00005693512,0.00001051186,0.00002979478,0.00003011599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004268507,0.00004029474,0.001289348,0.00008241832,0.00001305323,0.0001912535,0.00004473325,0.00002624516,0.996892,0.00003095982,0.00003045618,0.000932313],"study_design_scores_gemma":[0.00003316223,0.0007450468,0.05139304,0.00002235397,0.00008929532,0.001455557,0.0001292326,0.001317327,0.9434075,0.0001509126,0.001246795,0.000009718641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909541,0.005954763,0.002093219,0.000108655,0.00005098785,0.00002683824,0.0001630846,0.00003262292,0.0006157091],"genre_scores_gemma":[0.9950249,0.002124094,0.001724895,0.00004427252,0.00002983056,0.00003494161,0.0002613518,0.000007315699,0.0007484998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004661184,"threshold_uncertainty_score":0.001633763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00388462590531588,"score_gpt":0.2254162307883736,"score_spread":0.2215316048830577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}