{"id":"W2138539526","doi":"10.1371/journal.pone.0005438","title":"Lef1 Haploinsufficient Mice Display a Low Turnover and Low Bone Mass Phenotype in a Gender- and Age-Specific Manner","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Princess Margaret Cancer Centre","funders":"National Center for Research Resources; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; University of Southern California; Arthritis Foundation; National Cancer Institute; National Science Foundation; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Haploinsufficiency; Wnt signaling pathway; Endocrinology; Bone remodeling; Internal medicine; Osteoblast; Bone density; Phenotype; Biology; Chemistry; Medicine; Cell biology; Osteoporosis; Signal transduction; Genetics; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001934242,0.0007322371,0.000487285,0.001243174,0.0002128328,0.0003945935,0.0004085865,0.0007869543,0.003577743],"category_scores_gemma":[0.000149682,0.00044377,0.0002935651,0.0002798636,0.0004192063,0.0002997726,0.0002800323,0.0008105232,0.0009431806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002592756,"about_ca_system_score_gemma":0.0001575274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004849371,"about_ca_topic_score_gemma":0.001107461,"domain_scores_codex":[0.9997078,0.00002405626,0.00002811223,0.000100341,0.00008066669,0.00005900075],"domain_scores_gemma":[0.9995298,0.00004230229,0.0002546922,0.00002888397,0.00002817182,0.0001161292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001123474,0.00003145649,0.0006863879,0.00001541104,0.000004467082,0.0001972627,0.00001370636,0.00001990837,0.9979043,0.00005588773,0.00004357932,0.0009153699],"study_design_scores_gemma":[0.0001142843,0.001052393,0.08931001,0.00002873443,0.0000864551,0.007897936,0.0001220823,0.00106418,0.8938259,0.0002425167,0.006221163,0.00003440521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916835,0.001763908,0.002760971,0.0001305959,0.00003089437,0.00003109262,0.001775795,0.0002894338,0.001533922],"genre_scores_gemma":[0.9739412,0.001498611,0.003628515,0.0002163244,0.00004054093,0.0001367087,0.002368511,0.0002426148,0.01792695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003577743,"threshold_uncertainty_score":0.01196873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02093285762157283,"score_gpt":0.2094925670575509,"score_spread":0.1885597094359781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}