{"id":"W2138544728","doi":"10.1371/journal.pone.0007124","title":"Screen for Chemical Modulators of Autophagy Reveals Novel Therapeutic Inhibitors of mTORC1 Signaling","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":345,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Cancer Society Research Institute","keywords":"mTORC1; Autophagy; PI3K/AKT/mTOR pathway; Cell biology; Niclosamide; Rottlerin; Mechanistic target of rapamycin; Biology; Chemistry; Signal transduction; Biochemistry; Pharmacology; Apoptosis; Protein kinase C","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002589143,0.0006400162,0.0007014096,0.001003438,0.0002380505,0.000368613,0.0003549948,0.0004092277,0.002302006],"category_scores_gemma":[0.0002029262,0.0001992297,0.0004588792,0.0006405397,0.0001619764,0.0002262792,0.0002317352,0.0004247524,0.0005840498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000394836,"about_ca_system_score_gemma":0.0003967614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002697604,"about_ca_topic_score_gemma":0.00105983,"domain_scores_codex":[0.9997941,0.00002906787,0.00002287718,0.00004690589,0.00007513254,0.00003198283],"domain_scores_gemma":[0.9997961,0.00004642712,0.00005352762,0.0000199203,0.00005015887,0.00003385252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002408843,0.0003456213,0.001032928,0.0002171861,0.00006000599,0.0001749058,0.0000165213,0.0003827409,0.9869843,0.0001292046,0.0003002157,0.01011559],"study_design_scores_gemma":[0.0001651601,0.004508848,0.006289149,0.00003922044,0.000315553,0.0008125227,0.00002925409,0.001290599,0.9765689,0.00006742698,0.009894532,0.00001870468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9709853,0.009991149,0.008104112,0.0003423433,0.00009928327,0.0009413565,0.002775574,0.0003888556,0.006371931],"genre_scores_gemma":[0.9651386,0.007809491,0.01682949,0.0003360379,0.00007021096,0.0006037194,0.004115588,0.00007192108,0.005024982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002302006,"threshold_uncertainty_score":0.007701039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05433651801908413,"score_gpt":0.2789723222985533,"score_spread":0.2246358042794692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}