{"id":"W2138544728","doi":"10.1371/journal.pone.0007124","title":"Screen for Chemical Modulators of Autophagy Reveals Novel Therapeutic Inhibitors of mTORC1 Signaling","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":345,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Cancer Society Research Institute","keywords":"mTORC1; Autophagy; PI3K/AKT/mTOR pathway; Cell biology; Niclosamide; Rottlerin; Mechanistic target of rapamycin; Biology; Chemistry; Signal transduction; Biochemistry; Pharmacology; Apoptosis; Protein kinase C","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001537124,0.0001420957,0.0005359651,0.00008968065,0.00002193396,0.000002973591,0.0001020484,0.000118965,0.00006360281],"category_scores_gemma":[0.00007098434,0.0001262629,0.0001795718,0.0001553509,0.00006523266,0.00004725927,0.00001090695,0.0000931883,0.000002210688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003057163,"about_ca_system_score_gemma":0.00005735622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005659267,"about_ca_topic_score_gemma":5.268457e-8,"domain_scores_codex":[0.9987917,0.00001250329,0.0004316444,0.0001978907,0.0003606403,0.0002056056],"domain_scores_gemma":[0.9991585,0.00008675908,0.0001825578,0.0002855209,0.0001740137,0.0001126518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004145502,0.002647466,0.0007303241,0.0002115766,0.0004575944,0.000001387926,0.0001636268,0.000005633221,0.9926268,0.001188197,0.00002639341,0.001526418],"study_design_scores_gemma":[0.002141363,0.000611387,0.005159023,0.0005043278,0.0004304529,0.000001176802,0.00002254657,0.0005654605,0.9882249,0.002220248,0.000008956206,0.0001102201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971493,0.001031183,0.0007436594,0.0001849296,0.00001656814,0.0005970201,0.00003917546,0.00004643282,0.0001916637],"genre_scores_gemma":[0.9945771,0.00002165418,0.004536727,0.0004512703,0.0002260932,0.00001474674,0.00002700141,0.00002455604,0.0001208792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004428699,"threshold_uncertainty_score":0.5148854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05433651801908413,"score_gpt":0.2789723222985533,"score_spread":0.2246358042794692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}