{"id":"W2138566050","doi":"10.1101/cshperspect.a000935","title":"Transcriptional Regulation by P53","year":2010,"lang":"en","type":"review","venue":"Cold Spring Harbor Perspectives in Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":578,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; RNA polymerase II; Transcription factor; Chromatin; Gene; Mediator; Histone; Transcription (linguistics); Cell biology; Transcriptional regulation; Transcription preinitiation complex; Genetics; Regulation of gene expression; Promoter; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003154399,0.0006430121,0.0005992908,0.0007976773,0.0002253712,0.0006924088,0.0006097796,0.0008723987,0.001762538],"category_scores_gemma":[0.0002866523,0.0001879044,0.0001941956,0.0008194161,0.0008478643,0.0008457732,0.0006314598,0.001128856,0.002986054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006633337,"about_ca_system_score_gemma":0.0004115008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004567631,"about_ca_topic_score_gemma":0.0004713161,"domain_scores_codex":[0.9998571,0.00002135567,0.00001314013,0.00004433116,0.00004749567,0.00001668842],"domain_scores_gemma":[0.9998965,0.00003377446,0.00001722618,0.000009605895,0.00002927048,0.00001343545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009580107,0.00003858853,0.0003270052,0.003132334,0.00003093952,0.0004222069,0.00007911179,0.0004487458,0.03955442,0.01418422,0.02164101,0.9200457],"study_design_scores_gemma":[0.00001363882,0.00007281266,0.001448107,0.0004893441,0.00001940911,0.001576043,0.00004243372,0.0001348543,0.01215911,0.005496843,0.9785298,0.00001767011],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001151747,0.9888589,0.001464053,0.0006543167,0.0006025512,0.000009080039,0.00004689686,0.00004781247,0.00716468],"genre_scores_gemma":[0.00987255,0.9840367,0.0006572853,0.0004551206,0.0005035157,0.00001558336,0.00006846921,0.000008240957,0.004382443],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001762538,"threshold_uncertainty_score":0.00589627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02398937737902362,"score_gpt":0.3277406867659321,"score_spread":0.3037513093869085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}