{"id":"W2138567519","doi":"10.1128/jvi.74.10.4658-4665.2000","title":"Activation of Transcription Factors NF-κB and NF-IL-6 by Human Immunodeficiency Virus Type 1 Protein R (Vpr) Induces Interleukin-8 Expression","year":2000,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa; Université de Montréal","funders":"National Research Council Canada; Ontario HIV Treatment Network; Canadian Foundation for AIDS Research; amfAR, The Foundation for AIDS Research","keywords":"Biology; Jurkat cells; U937 cell; Enhancer; Cell culture; Transcription factor; HIV Long Terminal Repeat; Tumor necrosis factor alpha; Transcription (linguistics); Virology; NFKB1; Molecular biology; Gene expression; T cell; Immunology; Immune system; Gene; Long terminal repeat","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002155174,0.0001318381,0.0003039076,0.0001684484,0.0001241788,0.000008412287,0.0001473009,0.000232962,0.001197144],"category_scores_gemma":[0.00003392109,0.00009384203,0.00006980022,0.0000833417,0.0001997213,0.0001877102,0.0000173187,0.0003800142,0.00003453782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004164937,"about_ca_system_score_gemma":0.00004401425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009863717,"about_ca_topic_score_gemma":0.000005886193,"domain_scores_codex":[0.9988735,0.0002804738,0.0004195899,0.0001377158,0.00006428443,0.000224383],"domain_scores_gemma":[0.9994707,0.00005155983,0.0002559475,0.0001104722,0.0000810827,0.00003023343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008759106,0.0004428049,0.0006762744,0.00001116165,0.0001016252,0.000003979009,0.0007848565,0.000001867776,0.9896859,0.00002203643,0.0004064289,0.006987137],"study_design_scores_gemma":[0.00174319,0.003131518,0.009284221,0.00005500926,0.00002516224,0.0000510751,0.0001757638,3.833513e-7,0.9793168,0.0001365761,0.006005023,0.00007529815],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973044,0.002005263,0.00003665299,0.0001400353,0.00009610993,0.0001548551,0.00002867415,0.000007140241,0.0002268827],"genre_scores_gemma":[0.9991107,0.0003025933,0.00002601402,0.00001899974,0.00001378426,0.000003932056,0.00004742734,0.000008887768,0.0004676355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01036914,"threshold_uncertainty_score":0.9997159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01839806394241903,"score_gpt":0.2718064604588452,"score_spread":0.2534083965164262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}