{"id":"W2138567519","doi":"10.1128/jvi.74.10.4658-4665.2000","title":"Activation of Transcription Factors NF-κB and NF-IL-6 by Human Immunodeficiency Virus Type 1 Protein R (Vpr) Induces Interleukin-8 Expression","year":2000,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa; Université de Montréal","funders":"National Research Council Canada; Ontario HIV Treatment Network; Canadian Foundation for AIDS Research; amfAR, The Foundation for AIDS Research","keywords":"Biology; Jurkat cells; U937 cell; Enhancer; Cell culture; Transcription factor; HIV Long Terminal Repeat; Tumor necrosis factor alpha; Transcription (linguistics); Virology; NFKB1; Molecular biology; Gene expression; T cell; Immunology; Immune system; Gene; Long terminal repeat","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001825493,0.000592134,0.0002207459,0.0002408897,0.0001842652,0.0004483577,0.0001836966,0.0002544687,0.001077511],"category_scores_gemma":[0.000175327,0.0001485012,0.0003941326,0.0001209732,0.0003344332,0.000253029,0.0002396766,0.0007206594,0.0004661033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002369954,"about_ca_system_score_gemma":0.0001373088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001359114,"about_ca_topic_score_gemma":0.0001597882,"domain_scores_codex":[0.9997879,0.0000471183,0.00001484669,0.00004459939,0.00005140893,0.00005413423],"domain_scores_gemma":[0.9998804,0.00002278707,0.00003766898,0.00001914714,0.00001401177,0.00002590717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001237982,0.00004418174,0.0004150265,0.0000927661,0.000007774014,0.0001435164,0.00003878465,0.00006267914,0.9947988,0.0001604586,0.00005303205,0.004059138],"study_design_scores_gemma":[0.0000304618,0.0006097818,0.006633758,0.00004497169,0.00002420827,0.001252054,0.0000966773,0.0005955889,0.9816915,0.0005104548,0.008502387,0.000008239605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9640409,0.02154942,0.009705507,0.0002899365,0.0001413173,0.00005302667,0.0003553892,0.0002357533,0.003628655],"genre_scores_gemma":[0.9839125,0.006902864,0.0054531,0.00006860553,0.00005906918,0.00005360265,0.0005207354,0.00001569671,0.003013712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001077511,"threshold_uncertainty_score":0.003604591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01839806394241903,"score_gpt":0.2718064604588452,"score_spread":0.2534083965164262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}