{"id":"W2138579861","doi":"10.1073/pnas.0508259102","title":"A model of anthrax toxin lethal factor bound to protective antigen","year":2005,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Anthrax toxin; Mutagenesis; Docking (animal); Toxin; Bacillus anthracis; Enzyme; Chemistry; Antigen; Virulence factor; Biophysics; Biochemistry; Biology; Mutation; Recombinant DNA; Fusion protein; Genetics; Virulence; Bacteria; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001484763,0.0006441253,0.0008975672,0.000490364,0.001343993,0.001634049,0.002115396,0.003135682,0.02806027],"category_scores_gemma":[0.0005070183,0.0004813323,0.0008033453,0.000670664,0.001277588,0.001373718,0.001162725,0.001089384,0.001963756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001584647,"about_ca_system_score_gemma":0.001817666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02206818,"about_ca_topic_score_gemma":0.005826941,"domain_scores_codex":[0.9998471,0.00003553109,0.00000614077,0.0000301755,0.000031752,0.00004927249],"domain_scores_gemma":[0.9997873,0.00005856765,0.00002106391,0.00001671425,0.00003854442,0.00007784812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002626966,0.0001132331,0.0005500796,0.0001036828,0.00004951883,0.001048912,0.0001434916,0.9088126,0.005721582,0.07922382,0.002205917,0.001764535],"study_design_scores_gemma":[0.000229042,0.0001150015,0.0004230324,0.00001881219,0.00001960114,0.0001219283,0.0001056147,0.9758434,0.0005767152,0.01687273,0.005642945,0.00003120291],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6525786,0.001284795,0.09931154,0.006110148,0.000681385,0.0002885114,0.004879074,0.0009718167,0.2338941],"genre_scores_gemma":[0.9429708,0.0004601301,0.009884642,0.0002669286,0.00006040193,0.0002790234,0.001290235,0.0001526106,0.04463517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02806027,"threshold_uncertainty_score":0.09387094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06206971773316489,"score_gpt":0.3370406627704706,"score_spread":0.2749709450373057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}