{"id":"W2138580291","doi":"10.1053/j.gastro.2005.12.032","title":"Bile Acids Induce Ectopic Expression of Intestinal Guanylyl Cyclase C Through Nuclear Factor-κB and Cdx2 in Human Esophageal Cells","year":2006,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; Belgian American Educational Foundation","keywords":"CDX2; Ectopic expression; Soluble guanylyl cyclase; Chemistry; Guanylate cyclase 2C; GUCY2D; Guanylate cyclase; Cancer research; Internal medicine; Cell biology; Endocrinology; Biochemistry; Medicine; Biology; Transcription factor; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002071625,0.000293431,0.0002090999,0.0001988747,0.0001858657,0.0002914198,0.00011302,0.0001741613,0.001091691],"category_scores_gemma":[0.0001304624,0.00014401,0.0002320616,0.0002679926,0.0002576556,0.000138178,0.0002427239,0.0002722776,0.0003686909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003298878,"about_ca_system_score_gemma":0.0002852994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001180231,"about_ca_topic_score_gemma":0.001602481,"domain_scores_codex":[0.9998375,0.00002430638,0.00002285622,0.00003364549,0.00004643804,0.00003515152],"domain_scores_gemma":[0.9999024,0.00001973733,0.0000176696,0.0000237026,0.00001381688,0.00002273868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001222234,0.00001395013,0.0002986561,0.00003646143,0.000004419975,0.00005483028,0.00002432647,0.00003612845,0.9989114,0.0000419432,0.00001962929,0.0004361894],"study_design_scores_gemma":[0.00002847573,0.000208945,0.005057371,0.000005976104,0.00001493941,0.000321711,0.0000568832,0.000782592,0.9909497,0.00002528188,0.002544427,0.000003853363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944674,0.001738416,0.0021068,0.00005138046,0.00002710122,0.00003244074,0.0004161258,0.00005362503,0.001106675],"genre_scores_gemma":[0.9944099,0.0006808991,0.002054426,0.00002543047,0.00000624653,0.0000330065,0.0007085446,0.00001139133,0.002070157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001180231,"threshold_uncertainty_score":0.003652036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00810717480226379,"score_gpt":0.2452534134592315,"score_spread":0.2371462386569677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}