{"id":"W2138580291","doi":"10.1053/j.gastro.2005.12.032","title":"Bile Acids Induce Ectopic Expression of Intestinal Guanylyl Cyclase C Through Nuclear Factor-κB and Cdx2 in Human Esophageal Cells","year":2006,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; Belgian American Educational Foundation","keywords":"CDX2; Ectopic expression; Soluble guanylyl cyclase; Chemistry; Guanylate cyclase 2C; GUCY2D; Guanylate cyclase; Cancer research; Internal medicine; Cell biology; Endocrinology; Biochemistry; Medicine; Biology; Transcription factor; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008956708,0.0001565186,0.0002384082,0.00006384503,0.00005149536,0.000006684055,0.0001239794,0.0002077524,0.0000274459],"category_scores_gemma":[0.00001155399,0.0001383,0.00004729152,0.00004435259,0.0001578177,0.000006499927,0.0001249015,0.0001630145,0.000003450459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001569483,"about_ca_system_score_gemma":0.00001990803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000215834,"about_ca_topic_score_gemma":0.0001107053,"domain_scores_codex":[0.9987913,0.0001498823,0.0003381739,0.0003300658,0.00007175159,0.0003188245],"domain_scores_gemma":[0.9995635,0.000009218007,0.0001440479,0.0001959037,0.00003486882,0.00005245675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001108999,0.0001147272,0.200711,0.00003955693,0.000007212813,0.00001616065,0.00008226418,0.00002704999,0.7985075,0.00006254403,0.0002674505,0.00005367547],"study_design_scores_gemma":[0.003043925,0.003207779,0.5207705,0.0001418037,0.00001631681,0.000143449,0.0001480448,0.00001807414,0.4706471,0.0002260803,0.001447886,0.0001889758],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987178,0.0001736656,0.0001934091,0.00005485924,0.0001234565,0.0001591276,0.00001832856,0.00001014098,0.0005492115],"genre_scores_gemma":[0.9990985,0.00002778942,0.0004792584,0.0001165239,0.0001015259,0.000006577076,0.00004295062,0.00001809153,0.0001087624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3278604,"threshold_uncertainty_score":0.563971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00810717480226379,"score_gpt":0.2452534134592315,"score_spread":0.2371462386569677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}