{"id":"W2138602400","doi":"10.1128/aac.49.2.556-559.2005","title":"Generation and Characterization of Recombinant Influenza A (H1N1) Viruses Harboring Amantadine Resistance Mutations","year":2005,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":173,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; University of Oxford; GlaxoSmithKline","keywords":"Amantadine; Virology; Recombinant DNA; Biology; Influenza A virus; Virus; Mutant; Mutation; Viral replication; Recombinant virus; Virulence; Resistance mutation; Microbiology; Gene; Genetics; Reverse transcriptase; Polymerase chain reaction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000421212,0.0004342932,0.0003355953,0.0002140755,0.0001606892,0.0003000231,0.0002800793,0.0003517284,0.0004143811],"category_scores_gemma":[0.0004902416,0.0001951442,0.0003795694,0.0001719786,0.0001773857,0.0001589646,0.0001806162,0.0005830125,0.000392701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002597599,"about_ca_system_score_gemma":0.0001507959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006146731,"about_ca_topic_score_gemma":0.0005339669,"domain_scores_codex":[0.9997343,0.00007366714,0.00003072925,0.00004410367,0.00007754688,0.0000395926],"domain_scores_gemma":[0.9997794,0.00006752263,0.00004694266,0.00004407109,0.00003423676,0.00002789753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002982531,0.00002454151,0.0001094571,0.000009846642,0.000002612476,0.00002487856,0.00001337462,0.00004235176,0.9992977,0.00003738192,0.00001315687,0.0003947957],"study_design_scores_gemma":[0.00005163555,0.000997893,0.003061856,0.000005845343,0.0000273741,0.0009454617,0.00003529873,0.00143923,0.99041,0.00005010539,0.00296731,0.000008099766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918572,0.0004448431,0.006238861,0.00005861893,0.00002016839,0.0001390539,0.0005900017,0.00003888868,0.0006123351],"genre_scores_gemma":[0.964851,0.0007181341,0.02775998,0.00006465987,0.0000234914,0.0001525004,0.004284796,0.00006841856,0.00207708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006146731,"threshold_uncertainty_score":0.002227604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08208851332100944,"score_gpt":0.354604707021838,"score_spread":0.2725161937008286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}