{"id":"W2138635650","doi":"10.1038/sj.emboj.7600048","title":"Structural basis of ligand recognition by PABC, a highly specific peptide‐binding domain found in poly(A)‐binding protein and a HECT ubiquitin ligase","year":2003,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":110,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Concordia University; Biotechnology Research Institute; William Osler Health System","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; Chinese Academy of Agricultural Sciences; Howard Hughes Medical Institute","keywords":"Biology; Ubiquitin ligase; Ubiquitin; Peptide; Plasma protein binding; DNA ligase; Ubiquitin-Protein Ligases; Ligand (biochemistry); Domain (mathematical analysis); Cell biology; Binding site; Biochemistry; Biophysics; Computational biology; Receptor; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001106263,0.0001966436,0.0002159587,0.00009722664,0.0002399223,0.00009549514,0.0001583422,0.0001117782,0.00005703295],"category_scores_gemma":[0.0001531119,0.0001513745,0.00008354413,0.0001638975,0.0001120569,0.00001601297,0.00005131802,0.0003288662,0.000004732313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003566379,"about_ca_system_score_gemma":0.00007606555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001232711,"about_ca_topic_score_gemma":0.00001873564,"domain_scores_codex":[0.9984819,0.0003400012,0.0003972737,0.0002419449,0.0001857618,0.0003531338],"domain_scores_gemma":[0.9993421,0.00003911094,0.0002651678,0.0001734407,0.0000665575,0.0001136601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001592401,0.00002426324,0.0009851698,0.00002848522,0.00003431862,0.00001770509,0.0003370628,9.916286e-7,0.9954566,0.00007930116,0.0002697805,0.00260702],"study_design_scores_gemma":[0.001205423,0.0003197794,0.0002729694,0.0001908824,0.00001393824,0.0006833488,0.0007677292,0.000003697612,0.993145,0.001637054,0.001548036,0.0002121781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963067,0.002232375,0.0000644867,0.0001676226,0.00009905407,0.0003279502,0.00004479144,0.000005199232,0.0007518445],"genre_scores_gemma":[0.9982053,0.0002308874,0.001021786,0.00004595347,0.00018869,0.00001813461,0.00002311524,0.00002557875,0.0002405637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002394842,"threshold_uncertainty_score":0.6172873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01935440454187793,"score_gpt":0.2374119517279971,"score_spread":0.2180575471861192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}