{"id":"W2138635650","doi":"10.1038/sj.emboj.7600048","title":"Structural basis of ligand recognition by PABC, a highly specific peptide‐binding domain found in poly(A)‐binding protein and a HECT ubiquitin ligase","year":2003,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":110,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Concordia University; Biotechnology Research Institute; William Osler Health System","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; Chinese Academy of Agricultural Sciences; Howard Hughes Medical Institute","keywords":"Biology; Ubiquitin ligase; Ubiquitin; Peptide; Plasma protein binding; DNA ligase; Ubiquitin-Protein Ligases; Ligand (biochemistry); Domain (mathematical analysis); Cell biology; Binding site; Biochemistry; Biophysics; Computational biology; Receptor; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001395633,0.0002807699,0.0003691737,0.0001494615,0.0004791839,0.000533986,0.0005780339,0.0004977692,0.001142615],"category_scores_gemma":[0.0002661321,0.0002160524,0.0002660496,0.0001098913,0.0004564603,0.0002782548,0.0002266627,0.0008040154,0.0005160514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008352598,"about_ca_system_score_gemma":0.0004635928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001481302,"about_ca_topic_score_gemma":0.001200738,"domain_scores_codex":[0.9999034,0.00001661941,0.000004906816,0.00002077614,0.00002372502,0.00003052884],"domain_scores_gemma":[0.9998475,0.00003278772,0.00002352363,0.00001101448,0.00001950042,0.00006557503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005852737,0.0001315654,0.000991611,0.00007662236,0.00002113035,0.000784411,0.00004981031,0.002574904,0.9858241,0.005520163,0.0004217773,0.003018607],"study_design_scores_gemma":[0.0001195129,0.0002553372,0.008260979,0.00001370846,0.0000379525,0.00135225,0.00009064427,0.02918031,0.9539239,0.001550917,0.005185859,0.00002861741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899564,0.0009880331,0.005850394,0.0002281658,0.00005195235,0.00002678607,0.0001413488,0.0001281339,0.002628933],"genre_scores_gemma":[0.9966864,0.0001725164,0.001760312,0.0001033378,0.00001289624,0.00001265676,0.0002303143,0.00001035915,0.001011262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001481302,"threshold_uncertainty_score":0.006060243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01935440454187793,"score_gpt":0.2374119517279971,"score_spread":0.2180575471861192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}