{"id":"W2138642497","doi":"10.1158/1535-7163.mct-13-0420","title":"Novel Neutralizing Hedgehog Antibody MEDI-5304 Exhibits Antitumor Activity by Inhibiting Paracrine Hedgehog Signaling","year":2013,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada)","funders":"","keywords":"Paracrine signalling; Hedgehog; Hedgehog signaling pathway; Cancer research; Stromal cell; Smoothened; Sonic hedgehog; Biology; GLI1; Autocrine signalling; Cell biology; Signal transduction; Cell culture; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001522342,0.0004188961,0.0002636804,0.0001871309,0.00008305784,0.0002084999,0.0002383198,0.000282993,0.001395893],"category_scores_gemma":[0.00008069947,0.0001328477,0.0002115474,0.0001086351,0.0001301015,0.000131317,0.0001016636,0.0004876324,0.0003066325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002996669,"about_ca_system_score_gemma":0.0002092607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006959504,"about_ca_topic_score_gemma":0.001331531,"domain_scores_codex":[0.9999247,0.00001179259,0.000006300796,0.00001350535,0.00001998106,0.00002374241],"domain_scores_gemma":[0.9999554,0.000008905323,0.00001057813,0.000005559401,0.000005896763,0.00001366419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003144479,0.0001743468,0.0003070647,0.00005540065,0.00001344722,0.0000497267,0.00001029788,0.0002153994,0.9906251,0.000103166,0.0001523995,0.007979129],"study_design_scores_gemma":[0.0002046347,0.005028876,0.00454887,0.000009066827,0.00008306374,0.0007577396,0.00001387417,0.001828576,0.9833426,0.00004844557,0.004125717,0.000008355134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992523,0.001631004,0.002009023,0.0001149749,0.00002260228,0.00006673047,0.0002760836,0.000141821,0.003214791],"genre_scores_gemma":[0.9954921,0.0007945398,0.001630719,0.00007991712,0.00001073408,0.00002959572,0.0005238269,0.000008451204,0.001430237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001395893,"threshold_uncertainty_score":0.004669666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02851572192640275,"score_gpt":0.3049239239030884,"score_spread":0.2764082019766856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}