{"id":"W2138706637","doi":"10.1158/0008-5472.can-10-2227","title":"Telomerase Inhibition Potentiates the Effects of Genotoxic Agents in Breast and Colorectal Cancer Cells in a Cell Cycle–Specific Manner","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Telomerase; DNA damage; Telomere; Cancer research; Etoposide; Cell cycle; Biology; Topoisomerase inhibitor; Topoisomerase; DNA repair; Cancer cell; Cancer; Molecular biology; DNA; Chemotherapy; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006579247,0.0001715031,0.0003136717,0.0004746654,0.0001039011,0.00003312441,0.0001558482,0.0001473835,0.0002839892],"category_scores_gemma":[0.00005051831,0.0001268372,0.00004956768,0.0008985593,0.0004728195,0.00009991517,0.0001116339,0.001002781,0.00001587718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001748799,"about_ca_system_score_gemma":0.0002518402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004547769,"about_ca_topic_score_gemma":0.002641419,"domain_scores_codex":[0.9979048,0.0001956296,0.000307602,0.0004251207,0.0005809423,0.0005858872],"domain_scores_gemma":[0.9990214,0.0002772299,0.00006369175,0.0002830643,0.0001757863,0.0001788642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004271498,0.0002609493,0.06693733,0.0005435944,0.00001208902,0.0001833989,0.001291392,0.000008662321,0.921132,0.00001414724,0.0007956351,0.008393645],"study_design_scores_gemma":[0.001775134,0.00009635296,0.4055911,0.0003642978,0.00000910119,0.00001785611,0.0002200303,0.00008609163,0.5913805,0.00004782269,0.0003038369,0.0001079113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947059,0.002904231,6.419951e-7,0.0007640809,0.0002957385,0.001123754,0.00004694638,0.0000135602,0.0001452145],"genre_scores_gemma":[0.9937142,0.005402173,0.00002173507,0.00009415573,0.0001703604,0.0003398081,0.000008873606,0.00003240342,0.0002163512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3386538,"threshold_uncertainty_score":0.6874896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02176403391976288,"score_gpt":0.32845444200159,"score_spread":0.3066904080818271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}