{"id":"W2138718238","doi":"10.1523/jneurosci.5227-03.2004","title":"Mitogen- and Stress-Activated Protein Kinase 1 Mediates cAMP Response Element-Binding Protein Phosphorylation and Activation by Neurotrophins","year":2004,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":222,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"National Institute of Mental Health; Medical Research Council; Merck KGaA; GlaxoSmithKline; National Institutes of Health; Pfizer","keywords":"CREB; Protein kinase A; Ribosomal s6 kinase; Cell biology; Mitogen-activated protein kinase kinase; Phosphorylation; Neurotrophin; Kinase; MAP kinase kinase kinase; Biology; Molecular biology; Transcription factor; Biochemistry; Protein kinase B; P70-S6 Kinase 1; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002624813,0.000111816,0.000100734,0.00007094864,0.0001254472,0.00005872736,0.0001087041,0.00005607332,0.000001033041],"category_scores_gemma":[0.0005094011,0.000095874,0.00002441209,0.0001151784,0.00009579174,0.00003928633,0.00005374999,0.0001179489,2.545054e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001868576,"about_ca_system_score_gemma":0.0001009389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004949688,"about_ca_topic_score_gemma":0.000001024352,"domain_scores_codex":[0.9990974,0.00009141954,0.000221942,0.0002195564,0.0002103072,0.0001593734],"domain_scores_gemma":[0.9994169,0.0000111117,0.0002826181,0.0001001866,0.00007229553,0.0001168326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004075785,0.00004350652,0.0004363764,0.00001009058,0.000002284107,0.00001062993,0.00005240047,0.00002044003,0.9985973,0.00001434743,0.0000199272,0.000385134],"study_design_scores_gemma":[0.0007276388,0.001030666,0.005582298,0.00004681191,0.000004212741,0.00004978452,0.00003903965,0.00001382486,0.9912523,0.00004243754,0.001116285,0.00009470141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985749,0.0001033219,0.000576053,0.0003531966,0.0001076497,0.0002559152,0.00001952123,0.000004214707,0.000005292444],"genre_scores_gemma":[0.9994364,0.0000564202,0.00026939,0.00007075271,0.0000546753,0.000007881218,0.000004910717,0.00001012189,0.00008946358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007344985,"threshold_uncertainty_score":0.3909628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01271564260963545,"score_gpt":0.2392784170570495,"score_spread":0.2265627744474141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}